Fig. 1

Implementation of radiotherapy and treatment response for patient case 4; A GTV delineation in simulation CT image; B GTV delineation in simulation MR image; C Dose distribution in the radiation plan, protecting normal liver tissue and digestive tract as much as possible; D Primary tumour in right lobe of liver and portal vein tumour thrombosis in the pre-treatment MR image; E Four weeks after the combined treatment of radiation and apatinib, the primary tumour and tumour thrombus reduced obviously, and partial response was achieved according to mRECIST. (white arrow, primary tumour and portal vein tumour thrombus)