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Fig. 5 | BMC Cancer

Fig. 5

From: Improving anticancer effect of aPD-L1 through lowering neutrophil infiltration by PLAG in tumor implanted with MB49 mouse urothelial carcinoma

Fig. 5

Analysis of T cell populations in tumor tissue from mice treated with PLAG. a T cell populations in tumor tissue from mice treated with PLAG were analyzed. Among CD3+ cells, CD4+ cells and CD8+ cells were counted by FACS. b,c Tumor-infiltrating CD3+/CD4+ cells and CD3+/CD8+ cells were analyzed in tumor tissue from mice treated with PLAG. Compared with the tumor only: #P < 0.05, ##P < 0.01, ###P < 0.001; compared with the aPD-L1 only treatment group: $P < 0.05 (n = 3 for each experiment). N.S, not significant. Mean ± SD. d Tumor-infiltrating T cells in tumor tissue from mice treated with PLAG were confirmed by IHC staining with anti-CD8, anti-CD4, and anti-FoxP3 antibodies. e DAB-positive cells in tumor tissue stained with anti-CD8, anti-CD4, and anti-FoxP3 were analyzed. Compared with the tumor only: #P < 0.05, ##P < 0.01, ###P < 0.001; compared with the aPD-L1-only treatment group: $P < 0.05, $$P < 0.01, $$$P < 0.001 (each experiment n = 3 for each experiment). N.S, not significant. Mean ± SD

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