Fig. 7

Potential association between PTTG1 and tumor microenvironment in bladder cancer tissue samples. The immune infiltration levels of immune and stromal cells of TCGA-BLCA patients were quantified by using the Microenvironment cell populations-counter algorithm. A The immune microenvironment and clinical phenotypes were compared in normal bladder tissues, PTTG1 low expression bladder cancer tissue samples, and PTTG1 high expression bladder cancer tissue samples. B Higher PTTG1 mRNA expression levels indicated higher natural killer, cytotoxic lymphocyte, and monocyte lineage cell infiltration levels, and indicated lower neutrophils and endothelial cell infiltration levels. C The immune score was significantly lower in low PTTG1 mRNA expression bladder cancer tissue samples than that in high PTTG1 mRNA expression bladder cancer tissue samples or normal bladder tissue samples. However, no difference was detected in the stromal score of low PTTG1 mRNA expression bladder cancer tissue samples than that in high PTTG1 mRNA expression bladder cancer tissue samples (P < 0.05). D A high stromal score predicted poor prognosis in bladder carcinoma patients. E The prognostic value of the immune score in bladder carcinoma was insignificant (P < 0.05). **, P < 0.01; ****, P < 0.0001