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Table 5 Treatment response and outcomes

From: Poor treatment responses were related to poor outcomes in pediatric B cell acute lymphoblastic leukemia with KMT2A rearrangements

Demographics

n = 37a

%

pEFS

P = 

Dexamethasone response

 Negative

17

 

65.00 ± 12.68%

0.0442

 Positive

20

 

23.44 ± 10.61%

 

 DGR

23

 

60.71 ± 10.87%

0.0269

 DPR

14

 

15.71 ± 10.18%

 

BM status at TP1

 M1

34

 

43.09 ± 9.52%

-

 M2 or M3

3

 

-

 

FCM-MRD level at TP1

  < 0.01%

22

%

55.55 ± 11.24%

0.0221

  ≥ 0.01%

15

%

22.86 ± 12.90%

 

  < 1%

24

%

52.38 ± 10.70%

0.0175

  ≥ 1%

13

%

15.39 ± 13.01%

 

PCR-MRD level at TP1

 Negative

13

%

76.92 ± 11.69%

0.0031

 Positive

24

%

19.13 ± 9.43%

 

FCM-MRD level at TP2

  < 0.01%

25

%

57.69 ± 12.01%

 < 0.0001

  ≥ 0.01%

12

%

8.33 ± 7.98%

 

PCR-MRD level at TP2

 Negative

23

%

64.17 ± 10.93%

 < 0.0001

 Positive

14

%

8.33 ± 7.93%

 
  1. a patients without TRM