Table 1 Distribution of clinical and pathological variables among 205 neuroblastoma cases with and without 1p deletion
Variable | 1p deletion (n(%)) | 1p intact (n(%)) | Chi-square | P-value | |
|---|---|---|---|---|---|
Gender (n = 205) | Male | 17 (50.0) | 103 (60.2) | 1.224 | 0.269 |
Female | 17 (50.0) | 68 (39.8) | |||
INPC histology (n = 204) | FH | 11 (32.4) | 82 (48.2) | 2.881 | 0.090 |
UH | 23 (67.6) | 88 (51.8) | |||
Treatment status (n = 204) | Pre-chemotherapy | 7 (20.6) | 33 (19.4) | 0.025 | 0.875 |
Post-chemotherapy / relapse | 27 (79.4) | 137 (80.6) | |||
Specimen site (n = 205) | Primary tumor | 30 (88.2) | 158 (92.4) | 2.104 | 0.349 |
Metastatic tumor | 4 (11.8) | 10 (5.8) | |||
Both | - | 3 (1.8) | |||
MYCN (n = 205) | Amplified | 25 (73.5) | 26 (15.2) | 51.623 |  < 0.001 |
Non-amplified | 9 (26.5) | 145 (84.8) | |||
11p (n = 160) | Deleted | 8 (36.4) | 34 (24.6) | 1.348 | 0.246 |
Not deleted | 14 (63.6) | 104 (75.4) | |||
17q (n = 45) | Gain | 11 (91.7) | 21 (63.6) | 3.366 | 0.067 |
No gain | 1 (8.3) | 12 (36.4) | |||
Metastatic status (n = 193) | Metastatic | 27 (79.4) | 100 (62.9) | 3.397 | 0.065 |
Localized | 7 (20.6) | 59 (82.4) | |||
COG risk (n = 198) | High | 32 (94.1) | 122 (74.4) | 6.341 | 0.012 |
Low/intermediate | 2 (5.9) | 42 (25.6) | |||