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Table 2 Univariate and multivariate cox regression analysis of Ewing's sarcoma

From: A tool for predicting overall survival in patients with Ewing sarcoma: a multicenter retrospective study

 

Univariate Cox

Multivariate Cox

Characteristics

HR (CI 95%)

P

HR (CI 95%)

P

Age

 

Ref

Ref

Ref

Ref

 17-27

2.048 (1.419-2.956)

<0.001

1.856 (1.279 - 2.695)

<0.01

 

3.615 (2.531-5.163)

<0.001

4.036 (2.750 – 5.924)

<0.001

Sex

 Female

Ref

Ref

Ref

Ref

 Male

0.907 (0.680-1.211)

0.509

NA

NA

Primary Site

 Aix bone

Ref

Ref

Ref

Ref

 Limb bone

1.459 (1.042-2.044)

<0.05

1.091 (0.742 - 1.605)

0.658

 other

1.332 (0.904-1.962)

0.147

0.821 (0.522 - 1.290)

0.392

Laterality

 Left

Ref

Ref

Ref

Ref

 Not a paired site

1.659 (1.175-2.344)

<0.01

1.447 (0.981 – 2.134)

0.062

 right

1.255 (0.883-1.782)

0.205

1.166 (0.811 - 1.675)

0.408

T

 T1

Ref

Ref

Ref

Ref

 T2

1.748 (1.279-2.387)

<0.001

0.766 (0.501 - 1.173)

0.221

 T3

3.048 (1.457-6.378)

<0.01

0.867 (0.387 - 1.939)

0.727

 TX

4.109 (1.873-9.015)

<0.001

1.307 (0.552 - 3.095)

0.543

M

 M0

Ref

Ref

Ref

Ref

 M1

3.37 (2.536-4.484)

<0.001

1.538 (0.940 - 2.518)

0.087

Radiation

 No

Ref

Ref

Ref

Ref

 Yes

1.284(0.965-1.710)

0.087

NA

NA

Chemotherapy

 No

Ref

Ref

Ref

Ref

 Yes

0.411 (0.253-0.669)

<0.001

0.374 (0.222 - 0.630)

<0.001

Tumor Size

 ≤58

Ref

Ref

Ref

Ref

 59-128

2.301(1.548-3.420)

<0.001

2.656(1.643-4.292)

<0.001

 

3.532(2.283-5.465)

<0.001

3.900(2.174-6.996)

<0.001

Bone metastases

 No

Ref

Ref

Ref

Ref

 Yes

3.808 (2.753-5.267)

<0.001

2.228 (1.419- 3.500)

<0.01

Lung metastases

   

63

 No

Ref

Ref

Ref

Ref

 Yes

2.502 (1.824-3.431)

<0.001

1.386 (0.879 - 2.186)

0.160

Surgery

 No

Ref

Ref

Ref

Ref

 Yes

0.406(0.305-0.541)

<0.001

0.731 (0.526 – 1.016)

0.62