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Table 3 Summary of experimental measures and timing of assessment

From: Preventing the adverse cardiovascular consequences of allogeneic stem cell transplantation with a multi-faceted exercise intervention: the ALLO-Active trial protocol

 

Assessment

Method

Baseline

Post-Inpatient

12 Weeks Post-Inpatient

Primary Outcomes

  -VO2peak

CPET

✔

 

✔

  -Peak cardiac output

ExCMR

✔

 

✔

Secondary Outcomes

    

  -Quality of life

FACT-BMT

✔

✔

✔

  -Fatigue

FACIT-Fatigue

✔

✔

✔

  -Functional independence

CPET

✔

 

✔

Exploratory Outcomes

  -Vascular function

CMR

✔

 

✔

  -Cardiac mass

CMR

✔

 

✔

  -Diffuse myocardial fibrosis

CMR

✔

 

✔

  -Diastolic and systolic cardiac function

Echocardiography

✔

✔

✔

  -Thigh muscle volume

Thigh MRI

✔

 

✔

  -Thigh muscle fat fraction

Thigh MRI

✔

 

✔

  -Oxygen uptake kinetics

CPET

✔

 

✔

  -Body composition

DXA

✔

✔

✔

  -Cardiovascular biomarkers

Blood Samples

✔

✔

✔

  -Engraftment indices

Blood Samples

✔

✔

✔

  -Development of acute GVHD

Blood Samples

✔

✔

✔

  -Anxiety and depression

HADS

✔

✔

✔

  -Dietary intake

Diet Diary

✔

✔

✔

  -Habitual Physical Activity

Accelerometry/Fitabase

✔

✔

✔

  -Habitual Sedentary Time

Inclinometry/Fitabase

✔

✔

✔

  -Habitual Sleep Quality

Sleep Log/Fitabase

✔

✔

✔

  1. Cardiopulmonary exercise test (CPET), cardiac magnetic resonance imaging (CMR), exercise cardiac magnetic resonance imaging (ExCMR), functional assessment of cancer therapy with bone marrow transplant (FACT-BMT) questionnaire, functional assessment of chronic illness therapy (FACIT-fatigue) questionnaire, dual energy x-ray absorptiometry (DXA), graft versus host disease (GVHD), Hospital anxiety and depression scale (HADS), cardiovascular disease biomarkers include HbA1c, fasting glucose, troponin-I, BNP, LDL- and HDL-cholesterol, triglycerides