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Fig. 1 | BMC Cancer

Fig. 1

From: Polygenic risk scores indicate extreme ages at onset of breast cancer in female BRCA1/2 pathogenic variant carriers

Fig. 1

Standardized polygenic risk score (PRS) values per individual and Spearman’s rank correlation coefficients ρ. (Upper left) Overall breast cancer (BC) PRS versus estrogen receptor-positive (ER+) BC PRS in 183 BRCA1 pathogenic variant (PV) carriers who were either diagnosed with BC before the age of 35 years (early diagnosis, ED) or were unaffected at least until the age of 60 years (late/no diagnosis, LD). (Upper right) Overall BC PRS versus estrogen receptor-negative (ER-) BC PRS in the same sample. (Lower left) Overall BC PRS versus ER+ BC PRS in 112 BRCA2 PV carriers who belonged to either the LD or ED group. (Lower right) Overall BC PRS versus ER- BC PRS in the same sample

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BMC Cancer

ISSN: 1471-2407

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