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Table 3 Association between genetic predisposition to higher circulating C-reactive protein (CRP) and colorectal cancer outcome

From: Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations

 

CRC mortality

All-cause mortality

 

N event/N total

HR

(95% CI)

N event/N total

HR

(95% CI)

Weighted CRP -score

     

Tertile 1

99/271

1

Reference

124/271

1

Reference

Tertile 2

72/256

0.70

(0.50, 0.96)

97/256

0.68

(0.51, 0.90)

Tertile 3

94/289

0.86

(0.63, 1.17)

125/289

0.92

(0.70, 1.19)

p-trend

  

0.44

  

0.33

per score unit

0.95

(0.86, 1.05)

 

0.98

(0.90, 1.07)

rs1205

      

TT

35/82

1

Reference

41/82

1

Reference

CT

109/347

0.54

(0.35, 0.83)

144/347

0.58

(0.40, 0.85)

CC

121/387

0.58

(0.38, 0.88)

161/387

0.64

(0.44, 0.92)

p-trend

  

0.12

  

0.21

per C allele

0.85

(0.70, 1.04)

0.89

0.89

(0.75, 1.07)

TT vs. CT + CC (analogous to previous publications)

1.79

(1.20, 2.67)

 

1.64

(1.15, 2.34)

rs1800947

     

CG/GG

35/108

1

Reference

43/108

1

Reference

CC

230/707

0.99

(0.67, 1.46)

303/707

1.06

(0.75, 1.49)

p-trend

  

0.94

  

0.58

per C allele

1.01

(0.71, 1.46)

 

1.09

(0.80, 1.50)

rs1130864

     

GG

122/362

1

Reference

156/362

1.00

Reference

GA

115/363

0.88

(0.67, 1.16)

148/363

0.89

(0.70, 1.14)

AA

28/91

0.98

(0.63, 1.53)

42/91

1.17

(0.81, 1.68)

p-trend

  

0.61

  

0.85

per A allele

0.95

(0.78, 1.16)

 

1.02

(0.86, 1.21)

rs3093077

     

AA

236/715

1

Reference

308/715

1

Reference

AC/CC

29/101

0.84

(0.56, 1.26)

38/101

0.80

(0.56, 1.14)

p-trend

  

0.45

  

0.24

per C allele

0.86

(0.58, 1.27)

 

0.81

(0.58, 1.15)

  1. Stratified by country with time since colorectal cancer diagnosis as underlying time variable and adjusted for age at diagnosis (in years as a continuous variable), sex, tumor stage (I-IV, unknown), grade of tumor differentiation (well differentiated, moderately differentiated, poorly differentiated, or unknown), location of primary tumor (colon or rectum), and year of diagnosis
  2. Genotypes associated with lower CRP-concentrations are used as reference category unless indicated otherwise