Table 2 Association between pre-diagnostic C-reactive protein (CRP) concentrations and colorectal cancer outcome

Colorectal cancer

Quintile 1

91/248

1

Reference

112/248

1

Reference

Quintile 2

89/245

0.98

(0.71, 1.34)

114/245

0.94

(0.71, 1.24)

Quintile 3

87/249

0.80

(0.58, 1.10)

116/249

0.79

(0.60, 1.05)

Quintile 4

94/247

0.85

(0.62, 1.17)

124/247

0.84

(0.64, 1.11)

Quintile 5

94/246

0.92

(0.66, 1.28)

124/246

0.91

(0.68, 1.21)

p-trend

0.76

0.76

per doubling in CRP

0.95

(0.89, 1.01)

0.96

(0.91, 1.01)

Colorectal cancer, men only

Quintile 1

39/117

1

Reference

53/117

1

Reference

Quintile 2

48/134

1.00

(0.64, 1.57)

65/134

0.93

(0.63, 1.36)

Quintile 3

52/136

0.87

(0.55, 1.37)

67/136

0.76

(0.51, 1.13)

Quintile 4

45/114

1.00

(0.62, 1.60)

63/114

0.94

(0.63, 1.41)

Quintile 5

42/108

0.99

(0.60, 1.61)

58/108

0.89

(0.58, 1.34)

p-trend

0.94

0.86

per doubling in CRP

0.98

(0.90, 1.08)

0.97

(0.89, 1.05)

Colorectal cancer, women only

Quintile 1

52/131

1

Reference

59/131

1

Reference

Quintile 2

41/111

1.00

(0.62, 1.60)

49/111

0.98

(0.64, 1.50)

Quintile 3

35/113

0.74

(0.45, 1.21)

49/113

0.88

(0.57, 1.36)

Quintile 4

49/133

0.71

(0.45, 1.13)

61/133

0.74

(0.49, 1.12)

Quintile 5

52/138

0.77

(0.47, 1.25)

66/138

0.90

(0.59, 1.39)

p-trend

0.32

0.68

per doubling in CRP

0.91

(0.83, 1.00)

0.94

(0.87, 1.02)

p-interaction by sex

0.18

0.31

Colon cancer

Quintile 1

57/152

1

Reference

71/152

1

Reference

Quintile 2

45/139

0.88

(0.57, 1.36)

59/139

0.82

(0.56, 1.19)

Quintile 3

54/148

0.83

(0.54, 1.25)

75/148

0.80

(0.56, 1.15)

Quintile 4

63/160

0.78

(0.51, 1.17)

84/160

0.71

(0.50, 1.02)

Quintile 5

74/181

0.94

(0.63, 1.41)

92/181

0.83

(0.58, 1.18)

p-trend

0.89

0.61

per doubling in CRP

0.95

(0.88, 1.03)

0.93

(0.86, 0.99)

Colon cancer, men only

Quintile 1

21/67

1

Reference

31/67

1

Reference

Quintile 2

24/69

1.26

(0.64, 2.48)

33/69

1.02

(0.59, 1.77)

Quintile 3

29/77

0.92

(0.48, 1.76)

40/77

0.69

(0.40, 1.19)

Quintile 4

27/71

0.98

(0.50, 1.93)

39/71

0.79

(0.45, 1.37)

Quintile 5

30/77

1.00

(0.51, 1.96)

40/77

0.74

(0.42, 1.30)

p-trend

0.80

0.35

per doubling in CRP

0.98

(0.86, 1.11)

0.92

(0.82, 1.02)

Colon cancer, women only

Quintile 1

36/85

1

Reference

40/85

1

Reference

Quintile 2

21/70

0.62

(0.33, 1.18)

26/70

0.65

(0.37, 1.15)

Quintile 3

25/71

0.83

(0.44, 1.56)

35/71

0.99

(0.57, 1.70)

Quintile 4

36/89

0.60

(0.33, 1.09)

45/89

0.61

(0.36, 1.04)

Quintile 5

44/104

0.69

(0.38, 1.24)

52/104

0.80

(0.48, 1.35)

p-trend

0.48

0.74

per doubling in CRP

0.88

(0.78, 0.99)

0.91

(0.82, 1.00)

p-interaction by sex in colon cancer

0.39

0.60

Rectal cancer

Quintile 1

34/96

1

Reference

41/96

1

Reference

Quintile 2

44/106

1.05

(0.62, 1.76)

55/106

0.98

(0.62, 1.56)

Quintile 3

33/101

0.77

(0.45, 1.32)

41/101

0.78

(0.48, 1.26)

Quintile 4

31/87

0.89

(0.50, 1.58)

40/87

0.94

(0.57, 1.54)

Quintile 5

20/65

0.86

(0.44, 1.70)

32/65

1.18

(0.68, 2.07)

p-trend

0.59

0.45

per doubling in CRP

0.93

(0.83, 1.05)

1.01

(0.91, 1.12)

p-interaction by location

0.61

0.41

Rectal cancer, men only

Quintile 1

22/50

1

Reference

22/50

1

Reference

Quintile 2

32/65

1.18

(0.57, 2.43)

32/65

1.16

(0.62, 2.16)

Quintile 3

27/59

1.06

(0.49, 2.27)

27/59

0.93

(0.47, 1.81)

Quintile 4

24/43

1.02

(0.44, 2.36)

24/43

1.34

(0.66, 2.75)

Quintile 5

18/31

1.19

(0.46, 3.05)

18/31

1.51

(0.70, 3.27)

p-trend

0.87

0.25

per doubling in CRP

0.97

(0.82, 1.15)

1.06

(0.92, 1.22)

p-interaction by location in men

0.59

0.06

Rectal cancer, women only

Quintile 1

16/46

1

Reference

19/46

1

Reference

Quintile 2

20/41

1.05

(0.42, 2.63)

23/41

1.05

(0.48, 2.32)

Quintile 3

10/42

0.40

(0.14, 1.11)

14/42

0.47

(0.19, 1.15)

Quintile 4

13/44

0.60

(0.23, 1.57)

16/44

0.62

(0.27, 1.42)

Quintile 5

8/34

0.41

(0.13, 1.30)

14/34

0.75

(0.29, 1.95)

p-trend

0.12

0.47

per doubling in CRP

0.85

(0.69, 1.03)

0.90

(0.76, 1.07)

p-interaction by location in women

0.41

0.64

p-interaction by sex in rectal cancer

0.13

0.27

Stage I or II

Quintile 1

33/131

1

Reference

38/131

1

Reference

Quintile 2

16/107

0.62

(0.33, 1.18)

25/107

0.73

(0.43, 1.24)

Quintile 3

23/115

0.70

(0.39, 1.25)

33/115

0.75

(0.45, 1.24)

Quintile 4

14/100

0.58

(0.29, 1.16)

26/100

0.72

(0.42, 1.26)

Quintile 5

25/111

0.82

(0.44, 1.55)

42/111

0.98

(0.58, 1.67)

p-trend

0.97

0.52

per doubling in CRP

0.92

(0.82, 1.04)

0.97

(0.87, 1.07)

Stage III or IV

Quintile 1

52/81

1

Reference

60/81

1

Reference

Quintile 2

60/99

0.76

(0.51, 1.15)

71/99

0.76

(0.52, 1.10)

Quintile 3

57/103

0.72

(0.47, 1.09)

71/103

0.70

(0.48, 1.03)

Quintile 4

67/119

0.73

(0.49, 1.09)

81/119

0.68

(0.47, 0.99)

Quintile 5

62/113

0.72

(0.47, 1.11)

72/113

0.71

(0.48, 1.05)

p-trend

0.36

0.27

per doubling in CRP

0.93

(0.86, 1.01)

0.93

(0.86, 1.00)

p-interaction by stage

0.91

0.19