Fig. 4

Effect of selected ATIRE sites on host genes’ expression. A-G Correlations between editing levels of the ATIRE sites and expressions of host genes in LUSC tumor tissues. FPKM value were used to demonstrate the expression of each gene. P and r were calculated by the Spearman correlation test. H–K Expression changes of indicated genes in response to knock-down of ADAR1/2. siADAR1, siADAR2, and siControl refer to siRNA targeting ADAR1, ADAR2 and a scramble siRNA, respectively. P value was calculated by the Dunnett’s multiple comparisons test. L-R Differences in editing levels of selected ATIRE sites between LUSC tumor tissues and normal tissues. P value was calculated by the student’s t-test or unequal variances t-test