Fig. 1

Identification of survival-related ATIRE sites in LUSC patients. A The workflow of survival-related ATIRE sites determination for LUSC and ATIRE-based nomogram construction. B A Manhattan plot depicts associations between all ATIRE sites and LUSC survival, taking the P values in –log10 scale from the univariate Cox-PH model as the X-axis, the chromosomal location of the ATIRE sites as the Y-axis. Dotted orange line indicates the cut off of significance with P value as 0.001. C Cross-validation for the selection of optimal ATIRE sites (lambda) and dotted vertical lines. ATIRE: A-to-I RNA editing