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Fig. 4 | BMC Cancer

Fig. 4

From: Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma

Fig. 4

RTX-mediated killing of CD20+ B-cell lymphoma cultured in 3D spheroids. Percentage cell viability analyzed by a trypan blue b Annexin V or c propidium iodide (PI) of 3D cultured Raji, Daudi, BJAB, and GRANTA-519 cells treated with RTX isotypes or isotype controls in media supplemented with human plasma or where indicated, heat-inactivated (HI) plasma. Data are presented as the mean percentage cell viability ± SEM of 3-7 independent experiments. Statistical significance was determined by one-way ANOVA with Tukey post hoc test for multiple comparisons. Asterisk represents statistical significant difference between RTX and isotype control

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