The effect of HPV DNA and p16 status on the prognosis of patients with hypopharyngeal carcinoma: a meta-analysis

BMC Cancer

Table 3 Publication bias (Egger test) and sensitivity analysis (trim and fill method) performed for included studies

	Egger test (t,P)	Number of trim and fill	HR (95%CI), P^a	HR (95%CI), P^b
HPV DNA-OS	-2.75,0.023	0	0.610(0.538,0.692),0.0001	0.610(0.538,0.692) ,0.0001
HPV DNA-DFS	-0.23,0.855	-	0.601(0.311,1.161),0.130	-
p16-OS	-2.47,0.039	0	0.663(0.493,0.892),0.007	0.663(0.493,0.892),0.007
p16-DFS	-2.53,0.086	-	0.587(0.443,0.778),0.0001	-

Abbreviations: HPV DNA Human papilloma virus DNA, OS overall survival (OS), DFS disease-free survival
^a Original variation. ^b Variation after trim and fill

ISSN: 1471-2407