The effect of HPV DNA and p16 status on the prognosis of patients with hypopharyngeal carcinoma: a meta-analysis

BMC Cancer

Table 1 Characteristics of the Included Studies (HPV DNA)

Study	Region	No. of patients	Disease stage, No		HPV diagnostic method	HPV prevalence, %		Outcome	Quality score
Study	Region	No. of patients	I-II	III-IV	HPV diagnostic method	Positive	Negative	Outcome	Quality score
Hong et al., 201827	the U.S.	1931	NS	NS	NS	16.9	83.1	5-OS	8
Joo et al., 2013 [30]	Korea	64	NS	NS	ISH	10.9	89.1	5-OS,5-DFS	7
Ernoux et al., 2011 [21]	France	61	0	61	PCR	82.0	18.0	5-DFS	9
Lassen et al., 2017 [28]	Denmark	35	0	35	PCR	14.3	85.7	5-OS	7
Yang et al., 2016 [20]	China	46	9	37	PCR	26.1	73.9	> 5-OS	8
Burr et al., 2018 [19]	the U.S.	63	NS	NS	NS	15.9	84.1	3-OS	7
Dalianis et al.,2015 [29]	Sweden	142	NS	NS	PCR	4.9	95.1	3-OS	7
Marshall et al., 2020 [17]	the U.S.	640	85	555	PCR,ISH	26.1	73.9	3-OS	9
Abdel et al., 2020 [31]	the U.S.	1157	491	666	NS	23.9	76.1	> 5-OS	7
Tian et al., 2019 [26]	the U.S.	1805	165	1640	NS	10.6	49.5	5-OS	8
Joo et al., 2014 [18]	Korea	45	NS	NS	ISH	11.1	88.9	5-OS,5-DFS	7
Wendt et al., 2014 [33]	Sweden	109	21	88	PCR	6.4	93.6	5-OS	7

Abbreviations: HPV human papillomavirus, ISH in situ hybridization, NS not specified, OS overall survival, DFS disease-free survival, PCR polymerase chain reaction.

ISSN: 1471-2407