Table 1 Demographics and clinical characteristics of MPM patients from five EU countries (combined data)
From: Malignant pleural mesothelioma: treatment patterns and humanistic burden of disease in Europe
Characteristic | Overall (nĀ =ā1390) | Patients with eCRF only (nĀ =ā623) | Patients with eCRF and PSC (nĀ =ā767) | p value (eCRF only vs eCRF and PSC) |
|---|---|---|---|---|
Country breakdown, n | ||||
āFrance | 365 | 118 | 168 | n/a |
āGermany | 324 | 137 | 187 | Ā |
āItaly | 221 | 64 | 157 | Ā |
āSpain | 241 | 32 | 209 | Ā |
āUnited Kingdom | 348 | 202 | 46 | Ā |
Age, years | ||||
ān | 1390 | 623 | 767 | Ā |
āAge, mean (SD) | 67.5 (8.7) | 69.2 (8.3) | 66.1 (8.8) | <ā0.0001 (TT) |
āAge range, na (%b) | ||||
āā0āā¤64 | 443 (31.9) | 150 (24.1) | 293 (38.2) | <ā0.0001 (MW) |
āā65ā74 | 650 (46.8) | 308 (49.4) | 342 (44.6) | Ā |
āāā>ā75 | 297 (21.4) | 165 (26.5) | 132 (17.2) | Ā |
Gender, male, n (%) | 1032 (74.2) | 474 (76.1) | 558 (72.8) | 0.1748 (FE) |
Current employment status, n (%) | ||||
ān | 1378 | 612 | 766 | Ā |
āWorking full time | 85 (6.2) | 15 (2.5) | 70 (9.1) | <ā0.0001 (CH) |
āWorking part time | 52 (3.8) | 14 (2.3) | 38 (5.0) | Ā |
āOn long-term sick leave | 201 (14.6) | 83 (13.6) | 118 (15.4) | Ā |
āHomemaker | 82 (6.0) | 28 (4.6) | 54 (7.0) | Ā |
āStudent | 1 (0.1) | 0 | 1 (0.1) | Ā |
āRetired | 932 (67.6) | 459 (75.0) | 473 (61.7) | Ā |
āUnemployed | 25 (1.8) | 13 (2.1) | 12 (1.6) | Ā |
Current smoking status, n (%) | ||||
ān | 1368 | 611 | 757 | Ā |
āCurrent smoker | 379 (27.7) | 189 (30.9) | 190 (25.1) | <ā0.0001 (CH) |
āEx-smoker | 628 (45.9) | 296 (48.4) | 332 (43.9) | Ā |
āNever smoked | 361 (26.4) | 126 (20.6) | 235 (31.0) | Ā |
Time since diagnosis | ||||
ān | 1310 | 568 | 742 | 0.0059 (TT) |
āTime, days, mean (SD) | 298.5 (465.4) | 258.1 (298.8) | 329.4 (558.6) | Ā |
ECOG PS at initial diagnosis, n (%)c | ||||
ān | 1374 | 613 | 761 | Ā |
ā0 | 433 (32.2) | 184 (30.0) | 259 (34.0) | 0.0228 (MW) |
ā1 | 686 (49.9) | 304 (49.6) | 382 (50.2) | Ā |
ā2 | 225 (16.4) | 113 (18.4) | 112 (14.7) | Ā |
ā3 | 17 (1.2) | 9 (1.5) | 8 (1.1) | Ā |
ā4 | 3 (0.2) | 3 (0.5) | 0 (0.0) | Ā |
Current ECOG PS, n (%) | ||||
ān | 470 | 223 | 247 | Ā |
ā0 | 117 (24.9) | 40 (17.9) | 77 (31.2) | <ā0.0001 (MW) |
ā1 | 230 (48.9) | 109 (48.9) | 121 (49.0) | Ā |
ā2 | 108 (23.0) | 61 (27.4) | 47 (19.0) | Ā |
ā3 | 12 (2.6) | 10 (4.5) | 2 (0.8) | Ā |
ā4 | 3 (0.6) | 3 (1.3) | 0 (0.0) | Ā |
Stage of MPM at diagnosis, n (%) | ||||
ān | 1380 | 618 | 762 | Ā |
āStage 1 | 2 (0.1) | 1 (0.2) | 1 (0.1) | 0.0974 (CH) |
āStage 1a | 7 (0.5) | 5 (0.8) | 2 (0.3) | Ā |
āStage 1b | 38 (2.8) | 19 (3.1) | 19 (2.5) | Ā |
āStage 2 | 94 (6.8) | 38 (6.1) | 56 (7.3) | Ā |
āStage 3 | 303 (22.0) | 142 (23.0) | 161 (21.1) | Ā |
āStage 4 | 917 (66.4) | 399 (64.6) | 518 (68.0) | Ā |
āUnable to stage | 19 (1.4) | 14 (2.3) | 5 (0.7) | Ā |
Current stage of MPM, n (%) | ||||
ān | 1328 | 618 | 710 | Ā |
āStage 1 | 3 (0.2) | 2 (0.3) | 1 (0.1) | 0.0007 (CH) |
āStage 1a | 2 (0.2) | 1 (0.2) | 1 (0.1) | Ā |
āStage 1b | 18 (1.4) | 12 (1.9) | 6 (0.8) | Ā |
āStage 2 | 57 (4.3) | 38 (6.1) | 19 (2.7) | Ā |
āStage 3 | 235 (17.7) | 110 (17.8) | 125 (17.6) | Ā |
āStage 4 | 991 (74.6) | 438 (70.9) | 553 (77.9) | Ā |
āUnable to stage | 22 (1.7) | 17 (2.8) | 5 (0.7) | Ā |
Histology of MPM, n (%) | ||||
ān | 1349 | 604 | 745 | Ā |
āEpithelioid | 968 (71.8) | 420 (69.5) | 548 (73.6) | 0.0775 (CH) |
āBiphasic | 253 (18.8) | 115 (19.0) | 138 (18.5) | Ā |
āSarcomatoid | 128 (9.5) | 69 (11.4) | 59 (7.9) | Ā |
Resection status at diagnosis, n (%) | ||||
ān | 1363 | 615 | 748 | Ā |
āResectable | 77 (5.6) | 19 (3.1) | 58 (7.8) | 0.0002 (FE) |
āUnresectable | 1286 (94.4) | 596 (96.9) | 690 (92.2) | Ā |
History of asbestos exposure, n (%) | ||||
ān | 1192 | 574 | 618 | Ā |
āYes | 897 (75.3) | 476 (82.9) | 421 (68.1) | <ā0.0001 (FE) |
āNo | 295 (24.7) | 98 (17.1) | 197 (31.9) | Ā |