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Fig. 9 | BMC Cancer

Fig. 9

From: Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer

Fig. 9

Enriched ontology clusters for the cancer-associated fibroblast markers and upregulated genes in gastric cancer. A Dendrogram of the enriched ontology clusters (GO/KEGG terms, canonical pathways) for the CAF markers and upregulated genes in GC. B Network representation of enriched terms for a combined list of the CAF markers and upregulated genes in gastric cancer (GC). Each term is represented by a circle node, where its size is proportional to the number of the input genes that fall into that term. The nodes are presented as pie sectors where each pie sector is proportional to the number of hits originating from the CAF markers list (red) and upregulated genes in GC (blue). C The gene ontology terms for the same network nodes in B where each color represents different cluster identities given in the label. D Representation of the same network nodes in B and C colored by p-value, as shown in the color scale. B-D The black arrows show the nodes that fall into the Integrin α4β1 pathway in GC upregulated genes list. Only one node that falls into the Integrin α4β1 pathway shown with the red arrow was common in both the CAF markers list and the GC upregulated genes list. The data was analyzed, and the network layouts were prepared in Metascape.org

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