Fig. 8

Prognostic impact of the six key CAF markers and the CAF infiltration in TCGA cancers. Heatmap of risk scores for A the expression of COL1A1, COL1A2, COL3A1, COL5A1, FN1, and SPARC, B the cancer-associated fibroblast (CAF) infiltration, C the expression of COL1A1 and COL5A1 plus CAF infiltration in different cancers at TCGA dataset. A-C z-score > 0 (p < 0.05) indicates increased risk and z-score < 0 (p < 0.05) indicates decreased risk. ACC: adrenocortical carcinoma, BLCA: bladder urothelial carcinoma, KIRP: kidney renal papillary cell carcinoma, MESO: mesothelioma, and STAD: stomach adenocarcinoma. Data was extracted from TIMER 2.0. D Venn analysis of genes highly correlated (r ≥ 0.5) with COL1A1 and COL5A1 in TCGA samples of ACC, KIRP, and MESO. E The circos plots that show how genes from the input gene lists- 25 common genes detected by Venn analysis at (D) (red outer circle) vs. 38 upregulated genes in gastric cancer (blue outer circle)- overlap. The dark orange color at the inner circle represents the genes that appear in both lists and the light orange color represents genes that are unique to that gene list. Purple lines (upper circos plot) link the same genes that are shared by the two lists. Blue lines (lower circos plot) link the different genes which fall into the same ontology term. F Enriched ontology clusters (GO/KEGG terms, canonical pathways) for 25 common genes correlated with COL1A1 and COL5A1 in ACC, KIRP, and MESO (I) vs. 38 upregulated genes in GC (II). E-F Analysis was performed on Metascape.org. For a full list of TCGA cancer type abbreviations please refer to https://gdc.cancer.gov/resources-tcga-users/tcga-code-tables/tcga-study-abbreviations