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Fig. 2 | BMC Cancer

Fig. 2

From: Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer

Fig. 2

Identification and functional enrichment analysis of differentially expressed genes in gastric cancer. A Volcano plots of differentially expressed genes (DEGs) in four GEO datasets with the number of upregulated, downregulated genes and, the total number of DEGs detected in each dataset. Overlapping B DEGs, C upregulated genes, and D downregulated genes in four GEO datasets. Bubble plots of the most enriched GO terms for E upregulated genes, F downregulated genes, and G KEGG pathways for all DEGs (BP: GO-biological process, MF: GO-molecular function, and CC: GO-cellular compartment). H The circos plots show how genes from the CAF markers (27 genes, red outer arc) and upregulated genes in GC (38 genes, blue outer arc) lists overlap. On the inside, each arc represents a gene list, where each gene has a spot on the arc. The dark orange color represents the genes that appear in both lists and the light orange color represents genes that are unique to a single gene list. Purple lines (upper circos plot) link the same genes that are shared by the two lists. Blue lines (lower circos plot) link the different genes which fall into the same ontology term. The circos plots were prepared on Metascape.org

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