Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS)

Fig. 1

A Isoform-specific qRT-PCR of ASPP2κ in STS cell lines. A pool of microscopically tumor-free tissue (n = 15) deriving from STS patient samples (6 rhabdomyosarcoma, 9 liposarcoma) served as control. Statistical test: one-way ANOVA B Stress inducible, temperature-dependent expression levels of ASPPκ in STS cell lines as assessed by isoform-specific qRT-PCR. Statistical test: two-way ANOVA. C ASPP2κ-specific qRT-PCR assay to determine relative mRNA expression levels in rhabdomyosarcoma patient tissue (n = 15). A pool (n = 6) of tumor-free tissue derived from the same patients served as control. Patient samples were measured in technical triplicates. Statistical tests: unpaired t-test. D ASPP2κ-specific qRT-PCR assay to determine relative mRNA expression levels of tumor vs. tumor-free tissue from same individuals (n = 3). Statistical test: two-way ANOVA. ****p < 0.0001, ***p < 0.001, ** p < 0.01, *p < 0.05, ns (not significant); GAPDH served as housekeeping gene

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us