Survival-related indicators ALOX12B and SPRR1A are associated with DNA damage repair and tumor microenvironment status in HPV 16-negative head and neck squamous cell carcinoma patients

Table 5 The correlation analysis between the expression of SPRR1A and ALOX12B and the expression of cancer associated fibroblasts effector

Down-effector gene	Hub gene	Spearman’s coefficient	P value	Adjusted p value
ADORA2B	ALOX12B	−0.1703	0.0004	0.0013
ADORA2B	SPRR1A	−0.1822	0.0002	0.0011
CCL2	ALOX12B	−0.1225	0.0118	0.0882
CCL2	SPRR1A	−0.1893	0.0001	0.0014
CCL5	ALOX12B	−0.1719	0.0004	0.0022
CCL5	SPRR1A	−0.2548	< 0.001	< 0.001
CXCL12	ALOX12B	−0.2081	< 0.001	0.0003
CXCL12	SPRR1A	−0.2720	< 0.001	< 0.001
CXCR4	ALOX12B	−0.1739	0.0005	0.0024
CXCR4	SPRR1A	−0.2515	< 0.001	< 0.001
FAP	ALOX12B	−0.3224	< 0.001	< 0.001
FAP	SPRR1A	−0.4550	< 0.001	< 0.001
IGF1	ALOX12B	−0.1402	0.0050	0.0331
IGF1	SPRR1A	−0.1742	0.0005	0.0037
IGF2	ALOX12B	−0.0738	0.1405	0.3779
IGF2	SPRR1A	−0.1439	0.0039	0.0315
IL6	ALOX12B	−0.1210	0.0129	0.0573
IL6	SPRR1A	−0.1861	0.0002	0.0022
LIF	ALOX12B	−0.2408	< 0.001	< 0.001
LIF	SPRR1A	−0.2480	< 0.001	< 0.001
NT5E	ALOX12B	−0.2220	< 0.001	0.0002
NT5E	SPRR1A	−0.2635	< 0.001	< 0.001
PDGFA	ALOX12B	−0.3593	< 0.001	< 0.001
PDGFA	SPRR1A	−0.4350	< 0.001	< 0.001
PDGFB	ALOX12B	−0.2685	< 0.001	< 0.001
PDGFB	SPRR1A	−0.3193	< 0.001	< 0.001
PDGFC	ALOX12B	−0.2454	< 0.001	< 0.001
PDGFC	SPRR1A	−0.3551	< 0.001	< 0.001
PDGFD	ALOX12B	−0.1346	0.0070	0.0256
PDGFD	SPRR1A	−0.2002	0.0001	0.0003
TGFB1	ALOX12B	−0.1009	0.0436	0.1246
TGFB1	SPRR1A	−0.1852	0.0002	0.0027
TGFB2	ALOX12B	−0.2396	< 0.001	< 0.001
TGFB2	SPRR1A	−0.3247	< 0.001	< 0.001

ISSN: 1471-2407