Survival-related indicators ALOX12B and SPRR1A are associated with DNA damage repair and tumor microenvironment status in HPV 16-negative head and neck squamous cell carcinoma patients

Table 1 Multivariate survival analysis in the TCGA final discovery cohort

Overall survival		HR (95%CI)	P value
T stage	T4 vs. T1–3	0.76 (0.55–1.06)	0.105
N stage	N2–3 vs. N0–1	1.73 (1.22–2.44)	0.002**
Age	> 60 vs. < = 60	1.39 (1.00–1.95)	0.056
Sex	Male vs. Female	0.75 (0.53–1.05)	0.097
Grade category	G3 vs. G1–2	0.94 (0.66–1.35)	0.746
Subgroups	DDR-high/TM-low vs. DDR-high/TM-high	1.78 (1.15–2.75)	0.009**

HR Hazard ratio, CI Confidence interval, DDR-high High DNA repair level at transcriptome level, TM-high/−low Tumor microenvironment score -high/−low at transcriptome level, respectively. ** p value< 0.01

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