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Table 9 Network meta-analyses for efficacies of different CCRT regimens in the treatment of LA-NSCLC

From: A network meta-analysis for efficacies and toxicities of different concurrent chemoradiotherapy regimens in the treatment of locally advanced non-small cell lung cancer

OR (95% CI)

ORR

 A

2.48 (0.66,9.31)

0.17 (0.01,2.15)

1.14 (0.53,2.45)

1.00 (0.31,3.24)

2.67 (0.32,22.60)

0.22 (0.03,1.96)

2.84 (0.59,13.54)

1.63 (0.30,8.75)

 0.40 (0.11,1.52)

B

0.07 (0.00,1.20)

0.46 (0.10,2.13)

0.40 (0.07,2.37)

1.08 (0.09,13.32)

1.15 (0.50,2.63)

0.66 (0.08,5.60)

0.75 (0.05,10.78)

 6.02 (0.46,77.98)

14.90 (0.83,266.46)

C

6.86 (0.60,79.02)

6.02 (0.36,100.81)

16.07 (0.69,376.81)

17.07 (0.85,343.12)

9.83 (0.56,172.46)

11.14 (0.42,295.89)

 0.88 (0.41,1.89)

2.17 (0.47,10.04)

0.15 (0.01,1.68)

D

0.88 (0.22,3.57)

2.34 (0.32,17.22)

2.49 (0.44,14.19)

1.43 (0.32,6.39)

1.62 (0.18,14.46)

 1.00 (0.31,3.24)

2.48 (0.42,14.55)

0.17 (0.01,2.78)

1.14 (0.28,4.63)

E

2.67 (0.23,30.57)

2.84 (0.40,20.04)

1.63 (0.21,12.67)

1.85 (0.14,24.85)

 0.37 (0.04,3.17)

0.93 (0.08,11.45)

0.06 (0.00,1.46)

0.43 (0.06,3.14)

0.37 (0.03,4.29)

F

1.06 (0.08,14.98)

0.61 (0.16,2.30)

0.69 (0.28,1.70)

 4.45 (0.51,38.93)

0.87 (0.38,2.00)

0.06 (0.00,1.18)

0.40 (0.07,2.29)

0.35 (0.05,2.49)

0.94 (0.07,13.28)

G

0.58 (0.06,5.71)

0.65 (0.04,10.67)

 0.35 (0.07,1.68)

1.52 (0.18,12.86)

0.10 (0.01,1.79)

0.70 (0.16,3.11)

0.61 (0.08,4.75)

1.64 (0.44,6.14)

1.74 (0.18,17.21)

H

1.13 (0.23,5.61)

 0.61 (0.11,3.28)

1.34 (0.09,19.29)

0.09 (0.00,2.39)

0.62 (0.07,5.48)

0.54 (0.04,7.26)

1.44 (0.59,3.55)

1.53 (0.09,25.06)

0.88 (0.18,4.37)

I

 0.54 (0.05,5.48)

1.63 (0.10,25.37)

0.11 (0.00,3.09)

0.75 (0.08,7.33)

0.66 (0.05,9.56)

1.76 (0.58,5.31)

1.87 (0.11,32.85)

1.08 (0.19,6.03)

1.22 (0.64,2.32)

 0.66 (0.06,7.29)

0.74 (0.04,13.60)

0.05 (0.00,1.61)

0.34 (0.03,4.06)

0.30 (0.02,5.15)

0.80 (0.18,3.47)

0.85 (0.04,17.50)

0.49 (0.07,3.53)

0.55 (0.17,1.77)

 0.30 (0.02,3.99)

3.80 (0.76,19.08)

0.26 (0.02,3.88)

1.75 (0.53,5.80)

1.54 (0.34,6.83)

4.10 (0.40,41.96)

4.36 (0.71,26.72)

2.51 (0.37,17.01)

2.84 (0.23,34.36)

 1.54 (0.61,3.86)

1.34 (0.59,3.05)

0.09 (0.00,1.80)

0.62 (0.11,3.50)

0.54 (0.08,3.81)

1.44 (0.10,20.34)

1.53 (0.48,4.94)

0.88 (0.09,8.74)

1.00 (0.06,16.34)

 1.00 (0.24,4.18)

0.62 (0.03,11.72)

0.04 (0.00,1.38)

0.28 (0.02,3.51)

0.25 (0.01,4.44)

0.67 (0.14,3.08)

0.71 (0.03,15.06)

0.41 (0.05,3.08)

0.46 (0.13,1.60)

 0.54 (0.11,2.57)

0.76 (0.04,16.01)

0.05 (0.00,1.86)

0.35 (0.03,4.88)

0.31 (0.02,6.08)

0.82 (0.15,4.60)

0.87 (0.04,20.50)

0.50 (0.06,4.41)

0.57 (0.13,2.48)

 0.25 (0.02,3.45)

0.63 (0.03,15.96)

0.04 (0.00,1.80)

0.29 (0.02,5.00)

0.26 (0.01,6.08)

0.68 (0.09,5.17)

0.73 (0.03,20.31)

0.42 (0.04,4.69)

0.47 (0.08,2.90)

 0.31 (0.02,4.78)

1.33 (0.08,22.10)

0.09 (0.00,2.67)

0.61 (0.06,6.47)

0.54 (0.03,8.35)

1.44 (0.41,5.05)

1.53 (0.08,28.55)

0.88 (0.14,5.45)

1.00 (0.41,2.40)

1-year OS rate

 A

1.14 (0.57,2.29)

0.95 (0.64,1.41)

0.50 (0.16,1.58)

0.69 (0.14,3.27)

1.26 (0.26,6.23)

0.89 (0.37,2.15)

0.58 (0.20,1.72)

0.43 (0.06,2.92)

 0.88 (0.44,1.76)

B

0.84 (0.38,1.86)

0.44 (0.11,1.68)

0.60 (0.11,3.32)

0.78 (0.45,1.34)

0.51 (0.14,1.85)

0.38 (0.05,2.89)

0.09 (0.01,0.78)

 1.05 (0.71,1.55)

1.20 (0.54,2.66)

D

0.52 (0.16,1.77)

0.72 (0.16,3.26)

0.93 (0.35,2.45)

0.61 (0.22,1.68)

0.45 (0.07,2.94)

0.11 (0.02,0.80)

 2.00 (0.63,6.32)

2.28 (0.59,8.76)

1.91 (0.57,6.43)

E

1.37 (0.20,9.54)

1.77 (0.42,7.57)

1.17 (0.24,5.67)

0.86 (0.09,8.02)

0.21 (0.02,2.15)

 1.46 (0.31,6.96)

1.66 (0.30,9.21)

1.39 (0.31,6.31)

0.73 (0.10,5.07)

F

1.29 (0.21,7.79)

0.85 (0.28,2.62)

0.63 (0.21,1.90)

0.15 (0.04,0.55)

 0.79 (0.16,3.92)

1.29 (0.75,2.22)

1.07 (0.41,2.83)

0.56 (0.13,2.41)

0.77 (0.13,4.66)

G

0.66 (0.16,2.66)

0.48 (0.06,3.99)

0.12 (0.01,1.08)

 1.13 (0.47,2.73)

1.96 (0.54,7.09)

1.63 (0.60,4.49)

0.86 (0.18,4.16)

1.18 (0.38,3.63)

1.52 (0.38,6.16)

H

0.74 (0.15,3.57)

0.18 (0.03,0.99)

 1.71 (0.58,5.06)

2.65 (0.35,20.35)

2.22 (0.34,14.43)

1.16 (0.12,10.85)

1.59 (0.53,4.82)

2.06 (0.25,16.99)

1.36 (0.28,6.58)

I

0.25 (0.13,0.46)

 2.33 (0.34,15.77)

10.83 (1.28,91.52)

9.04 (1.25,65.44)

4.74 (0.47,48.38)

6.51 (1.81,23.34)

8.42 (0.93,76.18)

5.54 (1.01,30.39)

4.08 (2.16,7.72)

K

 9.49 (1.26,71.34)

10.54 (1.14,97.62)

8.80 (1.10,70.28)

4.62 (0.42,51.24)

6.33 (1.52,26.34)

8.19 (0.83,81.03)

5.39 (0.88,33.13)

3.97 (1.62,9.75)

0.97 (0.52,1.83)

 9.24 (1.12,76.48)

0.83 (0.31,2.21)

0.70 (0.32,1.53)

0.36 (0.10,1.39)

0.50 (0.09,2.75)

0.65 (0.21,1.98)

0.43 (0.12,1.53)

0.31 (0.04,2.40)

0.08 (0.01,0.65)

 0.73 (0.37,1.44)

1.34 (0.78,2.31)

1.12 (0.43,2.95)

0.59 (0.14,2.51)

0.81 (0.13,4.86)

1.05 (0.48,2.25)

0.69 (0.17,2.78)

0.51 (0.06,4.17)

0.12 (0.01,1.12)

 1.00 (0.39,2.53)

4.24 (0.43,41.88)

3.54 (0.41,30.29)

1.86 (0.16,21.88)

2.55 (0.56,11.69)

3.30 (0.31,34.70)

2.17 (0.33,14.41)

1.60 (0.56,4.55)

0.39 (0.17,0.90)

 1.18 (0.49,2.85)

8.22 (0.85,79.14)

6.86 (0.82,57.13)

3.60 (0.31,41.42)

4.94 (1.12,21.81)

6.39 (0.62,65.62)

4.20 (0.65,27.09)

3.10 (1.15,8.34)

0.76 (0.36,1.62)

 3.72 (0.42,32.92)

8.91 (1.01,78.75)

7.44 (0.98,56.51)

3.90 (0.37,41.48)

5.35 (1.38,20.68)

6.92 (0.73,65.46)

4.55 (0.78,26.44)

3.36 (1.54,7.29)

0.82 (0.53,1.28)

2-year OS rate

 A

0.78 (0.34,1.75)

1.00 (0.62,1.62)

0.30 (0.12,0.73)

1.25 (0.30,5.18)

0.62 (0.14,2.71)

0.80 (0.30,2.14)

1.11 (0.41,2.96)

0.39 (0.08,2.04)

 1.29 (0.57,2.91)

B

1.30 (0.50,3.32)

0.39 (0.12,1.29)

1.61 (0.31,8.29)

1.03 (0.58,1.81)

1.43 (0.40,5.11)

0.51 (0.08,3.17)

0.09 (0.01,0.77)

 1.00 (0.62,1.60)

0.77 (0.30,1.98)

D

0.30 (0.11,0.82)

1.25 (0.33,4.75)

0.79 (0.26,2.38)

1.10 (0.47,2.60)

0.39 (0.08,1.89)

0.07 (0.01,0.48)

 3.32 (1.37,8.04)

2.58 (0.78,8.56)

3.34 (1.22,9.11)

E

4.16 (0.78,22.15)

2.65 (0.70,9.98)

3.68 (0.98,13.80)

1.31 (0.20,8.47)

0.23 (0.02,2.06)

 0.80 (0.19,3.31)

0.62 (0.12,3.18)

0.80 (0.21,3.06)

0.24 (0.05,1.28)

F

0.64 (0.11,3.60)

0.88 (0.32,2.47)

0.31 (0.14,0.72)

0.05 (0.01,0.23)

 1.62 (0.37,7.13)

0.97 (0.55,1.71)

1.26 (0.42,3.78)

0.38 (0.10,1.42)

1.57 (0.28,8.87)

G

1.39 (0.34,5.61)

0.49 (0.07,3.36)

0.09 (0.01,0.81)

 1.25 (0.47,3.37)

0.70 (0.20,2.51)

0.91 (0.38,2.14)

0.27 (0.07,1.02)

1.13 (0.41,3.15)

0.72 (0.18,2.91)

H

0.36 (0.09,1.33)

0.06 (0.01,0.36)

 0.90 (0.34,2.41)

1.97 (0.31,12.31)

2.55 (0.53,12.33)

0.76 (0.12,4.95)

3.18 (1.38,7.31)

2.02 (0.30,13.78)

2.81 (0.75,10.53)

I

0.17 (0.05,0.56)

 2.54 (0.49,13.17)

11.38 (1.29,100.34)

14.74 (2.07,105.14)

4.42 (0.49,40.14)

18.37 (4.35,77.48)

11.70 (1.23,110.88)

16.25 (2.78,95.14)

5.78 (1.78,18.71)

K

 14.68 (1.94,110.81)

4.69 (0.38,58.02)

6.08 (0.59,62.70)

1.82 (0.14,23.12)

7.57 (1.12,51.28)

4.82 (0.37,63.51)

6.70 (0.77,58.69)

2.38 (0.43,13.34)

0.41 (0.12,1.45)

 6.05 (0.56,65.50)

0.98 (0.34,2.79)

1.26 (0.56,2.87)

0.38 (0.13,1.15)

1.58 (0.33,7.56)

1.00 (0.30,3.31)

1.39 (0.43,4.57)

0.50 (0.08,2.93)

0.09 (0.01,0.72)

 1.26 (0.65,2.45)

1.32 (0.75,2.34)

1.72 (0.57,5.16)

0.51 (0.14,1.94)

2.14 (0.38,12.09)

1.36 (0.61,3.04)

1.89 (0.47,7.64)

0.67 (0.10,4.58)

0.12 (0.01,1.10)

 1.00 (0.37,2.67)

5.00 (0.44,57.04)

6.47 (0.68,61.25)

1.94 (0.17,22.75)

8.06 (1.32,49.10)

5.14 (0.42,62.56)

7.13 (0.89,56.94)

2.54 (0.51,12.61)

0.44 (0.15,1.31)

 1.71 (0.63,4.60)

5.22 (0.51,53.29)

6.76 (0.81,56.66)

2.03 (0.19,21.28)

8.42 (1.61,44.00)

5.36 (0.49,58.63)

7.45 (1.06,52.13)

2.65 (0.63,11.06)

0.46 (0.20,1.03)

 6.44 (0.65,64.10)

7.82 (0.84,72.98)

10.13 (1.31,78.23)

3.04 (0.31,29.61)

12.62 (2.69,59.26)

8.04 (0.80,80.51)

11.17 (1.75,71.40)

3.97 (1.08,14.58)

0.69 (0.39,1.20)

3-year OS rate

 A

0.29 (0.08,1.02)

1.13 (0.80,1.58)

0.32 (0.15,0.72)

0.71 (0.18,2.75)

0.68 (0.13,3.66)

0.43 (0.11,1.69)

0.65 (0.27,1.57)

0.23 (0.05,1.11)

 3.50 (0.98,12.50)

B

3.94 (1.05,14.72)

1.13 (0.25,5.10)

2.47 (0.38,15.91)

1.51 (0.93,2.47)

2.26 (0.48,10.66)

0.80 (0.11,6.11)

0.16 (0.01,2.12)

 0.89 (0.63,1.25)

0.25 (0.07,0.95)

D

0.29 (0.12,0.69)

0.63 (0.17,2.34)

0.38 (0.09,1.57)

0.57 (0.25,1.30)

0.20 (0.04,0.95)

0.04 (0.00,0.37)

 3.09 (1.38,6.88)

0.88 (0.20,3.97)

3.47 (1.45,8.30)

E

2.18 (0.45,10.56)

1.34 (0.27,6.50)

1.99 (0.60,6.59)

0.71 (0.12,4.17)

0.14 (0.01,1.53)

 1.41 (0.36,5.49)

0.40 (0.06,2.60)

1.59 (0.43,5.92)

0.46 (0.09,2.22)

F

0.61 (0.09,4.19)

0.91 (0.33,2.55)

0.32 (0.14,0.73)

0.07 (0.01,0.39)

 1.47 (0.27,7.89)

0.66 (0.40,1.08)

2.60 (0.64,10.62)

0.75 (0.15,3.64)

1.64 (0.24,11.20)

G

1.49 (0.29,7.60)

0.53 (0.07,4.28)

0.11 (0.01,1.47)

 2.31 (0.59,9.05)

0.44 (0.09,2.09)

1.74 (0.77,3.96)

0.50 (0.15,1.66)

1.10 (0.39,3.06)

0.67 (0.13,3.42)

H

0.36 (0.10,1.32)

0.07 (0.01,0.56)

 1.55 (0.64,3.77)

1.25 (0.16,9.51)

4.91 (1.05,23.03)

1.41 (0.24,8.33)

3.09 (1.37,6.97)

1.89 (0.23,15.26)

2.82 (0.76,10.44)

I

0.20 (0.04,0.97)

 4.37 (0.90,21.24)

6.11 (0.47,79.14)

24.05 (2.67,216.31)

6.92 (0.65,73.55)

15.11 (2.60,87.95)

9.24 (0.68,125.50)

13.79 (1.80,105.85)

4.89 (1.03,23.34)

K

 21.37 (2.31,197.35)

2.96 (0.09,100.24)

11.66 (0.45,305.57)

3.36 (0.11,98.61)

7.33 (0.37,145.80)

4.48 (0.13,156.97)

6.69 (0.28,157.83)

2.37 (0.13,42.18)

0.48 (0.04,5.44)

 10.36   (0.39,276.40)

0.57 (0.14,2.32)

2.23 (1.10,4.49)

0.64 (0.23,1.76)

1.40 (0.32,6.20)

0.86 (0.19,3.82)

1.28 (0.43,3.75)

0.45 (0.08,2.47)

0.09 (0.01,0.93)

 1.98 (1.07,3.65)

1.12 (0.67,1.88)

4.41 (1.07,18.18)

1.27 (0.26,6.23)

2.77 (0.40,19.13)

1.70 (0.83,3.46)

2.53 (0.49,12.99)

0.90 (0.11,7.30)

0.18 (0.01,2.50)

 1.00 (0.42,2.39)

3.22 (0.19,55.57)

12.68 (1.01,158.37)

3.65 (0.25,52.76)

7.97 (0.92,68.88)

4.87 (0.27,87.71)

7.27 (0.67,79.21)

2.58 (0.35,19.02)

0.53 (0.15,1.83)

 3.92 (0.99,15.49)

2.41 (0.16,37.41)

9.51 (0.86,105.09)

2.74 (0.21,35.26)

5.98 (0.80,44.70)

3.66 (0.23,59.15)

5.45 (0.57,52.18)

1.94 (0.31,12.19)

0.40 (0.15,1.05)

 11.26 (0.88,143.99)

2.56 (0.18,36.42)

10.10 (1.01,101.01)

2.91 (0.25,34.10)

6.35 (0.96,42.09)

3.88 (0.26,57.66)

5.79 (0.67,49.81)

2.06 (0.37,11.34)

0.42 (0.21,0.84)

OR (95% CI)

ORR

 A

1.85 (0.18,18.76)

1.52 (0.14,16.79)

3.34 (0.25,44.59)

0.65 (0.26,1.64)

1.00 (0.24,4.18)

1.85 (0.39,8.79)

4.00 (0.29,55.28)

3.25 (0.21,50.55)

 0.40 (0.11,1.52)

0.61 (0.04,9.54)

1.35 (0.07,24.78)

0.26 (0.05,1.32)

0.75 (0.33,1.70)

1.62 (0.09,30.61)

1.31 (0.06,27.65)

1.58 (0.06,39.69)

0.75 (0.05,12.47)

 6.02 (0.46,77.98)

9.14 (0.32,258.35)

20.11 (0.62,652.30)

3.92 (0.26,59.63)

11.12 (0.55,223.19)

24.08 (0.72,801.66)

19.58 (0.54,712.41)

23.49 (0.55,996.17)

11.19 (0.38,333.91)

 0.88 (0.41,1.89)

1.33 (0.14,13.01)

2.93 (0.25,34.88)

0.57 (0.17,1.89)

1.62 (0.29,9.22)

3.51 (0.28,43.32)

2.86 (0.20,39.81)

3.43 (0.20,58.65)

1.63 (0.15,17.24)

 1.00 (0.31,3.24)

1.52 (0.10,22.04)

3.34 (0.19,57.48)

0.65 (0.15,2.90)

1.85 (0.26,13.03)

4.00 (0.23,71.05)

3.25 (0.16,64.34)

3.90 (0.16,92.67)

1.86 (0.12,28.86)

 0.37 (0.04,3.17)

0.57 (0.19,1.72)

1.25 (0.29,5.44)

0.24 (0.02,2.50)

0.69 (0.05,9.74)

1.50 (0.32,6.92)

1.22 (0.22,6.83)

1.46 (0.19,11.06)

0.70 (0.20,2.45)

 4.45 (0.51,38.93)

0.54 (0.03,9.41)

1.18 (0.06,24.28)

0.23 (0.04,1.41)

0.65 (0.20,2.10)

1.41 (0.07,29.96)

1.15 (0.05,26.96)

1.38 (0.05,38.47)

0.66 (0.04,12.27)

 0.35 (0.07,1.68)

0.93 (0.17,5.21)

2.05 (0.28,14.77)

0.40 (0.06,2.71)

1.13 (0.11,11.19)

2.45 (0.32,18.50)

1.99 (0.23,17.49)

2.39 (0.21,26.80)

1.14 (0.18,7.06)

 0.61 (0.11,3.28)

0.82 (0.43,1.56)

1.81 (0.56,5.77)

0.35 (0.03,4.26)

1.00 (0.06,16.30)

2.16 (0.63,7.46)

1.76 (0.40,7.65)

2.11 (0.34,12.93)

1.00 (0.42,2.42)

 0.54 (0.05,5.48)

K

2.20 (0.84,5.79)

0.43 (0.03,5.63)

1.22 (0.07,21.37)

2.64 (0.91,7.59)

2.14 (0.57,8.04)

2.57 (0.47,14.01)

1.22 (0.67,2.23)

 0.66 (0.06,7.29)

0.45 (0.17,1.20)

L

0.19 (0.01,3.05)

0.55 (0.03,11.38)

1.20 (0.29,5.02)

0.97 (0.19,5.02)

1.17 (0.17,8.23)

0.56 (0.18,1.74)

 0.30 (0.02,3.99)

2.33 (0.18,30.58)

5.13 (0.33,80.24)

M

2.84 (0.46,17.36)

6.14 (0.38,99.29)

4.99 (0.28,90.23)

5.99 (0.27,130.65)

2.86 (0.20,40.14)

 1.54 (0.61,3.86)

0.82 (0.05,14.42)

1.81 (0.09,37.21)

0.35 (0.06,2.16)

N

2.16 (0.10,45.90)

1.76 (0.07,41.32)

2.11 (0.08,58.95)

1.01 (0.05,18.80)

 1.00 (0.24,4.18)

0.38 (0.13,1.09)

0.84 (0.20,3.50)

0.16 (0.01,2.63)

0.46 (0.02,9.80)

O

0.81 (0.15,4.42)

0.98 (0.13,7.20)

0.46 (0.14,1.57)

 0.54 (0.11,2.57)

0.47 (0.12,1.75)

1.03 (0.20,5.29)

0.20 (0.01,3.62)

0.57 (0.02,13.33)

1.23 (0.23,6.69)

P

1.20 (0.14,10.30)

0.57 (0.13,2.44)

 0.25 (0.02,3.45)

0.39 (0.07,2.12)

0.86 (0.12,6.03)

0.17 (0.01,3.64)

0.47 (0.02,13.21)

1.02 (0.14,7.56)

0.83 (0.10,7.15)

Q

0.48 (0.08,2.88)

 0.31 (0.02,4.78)

0.82 (0.45,1.49)

1.80 (0.57,5.61)

0.35 (0.02,4.92)

0.99 (0.05,18.57)

2.15 (0.64,7.26)

1.75 (0.41,7.48)

2.10 (0.35,12.68)

R

1-year OS rate

 A

0.11 (0.01,0.79)

0.11 (0.01,0.90)

1.37 (0.69,2.71)

1.00 (0.39,2.53)

0.85 (0.35,2.05)

0.27 (0.03,2.38)

  

 0.88 (0.44,1.76)

0.09 (0.01,0.88)

1.20 (0.45,3.19)

0.74 (0.43,1.28)

0.24 (0.02,2.33)

0.12 (0.01,1.17)

0.11 (0.01,0.99)

  

 1.05 (0.71,1.55)

0.11 (0.01,0.91)

1.44 (0.65,3.16)

0.89 (0.34,2.34)

0.28 (0.03,2.41)

0.15 (0.02,1.21)

0.13 (0.02,1.02)

  

 2.00 (0.63,6.32)

0.22 (0.02,2.40)

2.74 (0.72,10.44)

1.70 (0.40,7.24)

0.54 (0.05,6.33)

0.28 (0.02,3.19)

0.26 (0.02,2.72)

  

 1.46 (0.31,6.96)

0.16 (0.04,0.66)

2.00 (0.36,10.99)

1.24 (0.21,7.45)

0.39 (0.09,1.80)

0.20 (0.05,0.89)

0.19 (0.05,0.72)

  

 0.79 (0.16,3.92)

0.12 (0.01,1.21)

1.54 (0.51,4.72)

0.96 (0.44,2.06)

0.30 (0.03,3.19)

0.16 (0.02,1.61)

0.14 (0.02,1.37)

  

 1.13 (0.47,2.73)

0.19 (0.03,1.14)

2.35 (0.65,8.45)

1.45 (0.36,5.89)

0.46 (0.07,3.06)

0.24 (0.04,1.53)

0.22 (0.04,1.28)

  

 1.71 (0.58,5.06)

0.25 (0.10,0.62)

3.19 (0.42,24.31)

1.97 (0.24,16.25)

0.63 (0.22,1.78)

0.32 (0.12,0.87)

0.30 (0.14,0.65)

  

 2.33 (0.34,15.77)

1.03 (0.55,1.93)

13.00 (1.55,109.35)

8.05 (0.89,72.86)

2.55 (1.11,5.85)

1.32 (0.62,2.81)

1.22 (0.78,1.89)

  

 9.49 (1.26,71.34)

L

12.65 (1.37,116.66)

7.84 (0.79,77.50)

2.48 (0.88,7.04)

1.28 (0.48,3.44)

1.18 (0.55,2.56)

  

 9.24 (1.12,76.48)

0.08 (0.01,0.73)

M

0.62 (0.20,1.89)

0.20 (0.02,1.93)

0.10 (0.01,0.97)

0.09 (0.01,0.82)

  

 0.73 (0.37,1.44)

0.13 (0.01,1.26)

1.61 (0.53,4.93)

N

0.32 (0.03,3.33)

0.16 (0.02,1.68)

0.15 (0.02,1.43)

  

 1.00 (0.39,2.53)

0.40 (0.14,1.14)

5.09 (0.52,50.06)

3.16 (0.30,33.19)

O

0.52 (0.17,1.59)

0.48 (0.19,1.22)

  

 1.18 (0.49,2.85)

0.78 (0.29,2.09)

9.87 (1.03,94.58)

6.11 (0.60,62.76)

1.94 (0.63,5.95)

P

0.92 (0.38,2.22)

  

 3.72 (0.42,32.92)

0.84 (0.39,1.83)

10.69 (1.21,94.11)

6.62 (0.70,62.61)

2.10 (0.82,5.37)

1.08 (0.45,2.61)

R

  

2-year OS rate

 A

0.07 (0.01,0.51)

0.17 (0.02,1.79)

0.79 (0.41,1.54)

1.00 (0.37,2.67)

0.59 (0.22,1.58)

0.16 (0.02,1.54)

  

 1.29 (0.57,2.91)

0.21 (0.02,2.64)

1.02 (0.36,2.93)

0.76 (0.43,1.33)

0.20 (0.02,2.29)

0.19 (0.02,1.96)

0.13 (0.01,1.19)

  

 1.00 (0.62,1.60)

0.16 (0.02,1.70)

0.79 (0.35,1.79)

0.58 (0.19,1.75)

0.15 (0.02,1.46)

0.15 (0.02,1.24)

0.10 (0.01,0.76)

  

 3.32 (1.37,8.04)

0.55 (0.04,6.96)

2.64 (0.87,7.97)

1.95 (0.52,7.35)

0.52 (0.04,6.05)

0.49 (0.05,5.19)

0.33 (0.03,3.21)

  

 0.80 (0.19,3.31)

0.13 (0.02,0.89)

0.63 (0.13,3.04)

0.47 (0.08,2.65)

0.12 (0.02,0.76)

0.12 (0.02,0.62)

0.08 (0.02,0.37)

  

 1.62 (0.37,7.13)

0.21 (0.02,2.73)

1.00 (0.30,3.28)

0.73 (0.33,1.64)

0.19 (0.02,2.37)

0.19 (0.02,2.04)

0.12 (0.01,1.25)

  

 1.25 (0.47,3.37)

0.15 (0.02,1.31)

0.72 (0.22,2.35)

0.53 (0.13,2.14)

0.14 (0.02,1.12)

0.13 (0.02,0.94)

0.09 (0.01,0.57)

  

 0.90 (0.34,2.41)

0.42 (0.07,2.35)

2.02 (0.34,11.90)

1.49 (0.22,10.14)

0.39 (0.08,1.96)

0.38 (0.09,1.58)

0.25 (0.07,0.93)

  

 2.54 (0.49,13.17)

2.43 (0.69,8.54)

11.65 (1.39,97.88)

8.59 (0.91,81.54)

2.28 (0.76,6.79)

2.18 (0.97,4.92)

1.46 (0.83,2.55)

  

 14.68 (1.94,110.81)

L

4.81 (0.41,56.97)

3.54 (0.27,46.70)

0.94 (0.18,4.97)

0.90 (0.20,4.03)

0.60 (0.15,2.38)

  

 6.05 (0.56,65.50)

0.21 (0.02,2.47)

M

0.74 (0.22,2.43)

0.20 (0.02,2.14)

0.19 (0.02,1.83)

0.12 (0.01,1.13)

  

 1.26 (0.65,2.45)

0.28 (0.02,3.72)

1.36 (0.41,4.48)

N

0.27 (0.02,3.23)

0.25 (0.02,2.78)

0.17 (0.02,1.70)

  

 1.00 (0.37,2.67)

1.06 (0.20,5.64)

5.12 (0.47,55.93)

3.77 (0.31,46.00)

O

0.96 (0.25,3.74)

0.64 (0.19,2.18)

  

 1.71 (0.63,4.60)

1.11 (0.25,4.98)

5.34 (0.55,52.15)

3.94 (0.36,43.11)

1.04 (0.27,4.08)

P

0.67 (0.25,1.79)

  

 6.44 (0.65,64.10)

1.67 (0.42,6.61)

8.01 (0.89,72.40)

5.91 (0.59,59.20)

1.57 (0.46,5.34)

1.50 (0.56,4.02)

R

  

3-year OS rate

 A

0.05 (0.01,0.43)

0.10 (0.00,2.57)

0.51 (0.27,0.93)

1.00 (0.42,2.39)

0.26 (0.06,1.01)

0.09 (0.01,1.14)

  

 3.50 (0.98,12.50)

0.34 (0.01,11.43)

1.77 (0.43,7.27)

0.89 (0.53,1.50)

0.31 (0.02,5.36)

0.41 (0.03,6.42)

0.39 (0.03,5.54)

  

 0.89 (0.63,1.25)

0.09 (0.00,2.25)

0.45 (0.22,0.91)

0.23 (0.06,0.93)

0.08 (0.01,0.99)

0.11 (0.01,1.16)

0.10 (0.01,0.99)

  

 3.09 (1.38,6.88)

0.30 (0.01,8.75)

1.56 (0.57,4.28)

0.79 (0.16,3.87)

0.27 (0.02,3.96)

0.37 (0.03,4.70)

0.34 (0.03,4.03)

  

 1.41 (0.36,5.49)

0.14 (0.01,2.71)

0.71 (0.16,3.17)

0.36 (0.05,2.49)

0.13 (0.01,1.09)

0.17 (0.02,1.25)

0.16 (0.02,1.04)

  

 1.47 (0.27,7.89)

0.22 (0.01,7.81)

1.17 (0.26,5.21)

0.59 (0.29,1.20)

0.21 (0.01,3.70)

0.27 (0.02,4.43)

0.26 (0.02,3.83)

  

 2.31 (0.59,9.05)

0.15 (0.01,3.53)

0.78 (0.27,2.30)

0.40 (0.08,2.03)

0.14 (0.01,1.50)

0.18 (0.02,1.76)

0.17 (0.02,1.49)

  

 1.55 (0.64,3.77)

0.42 (0.02,7.49)

2.21 (0.40,12.04)

1.11 (0.14,9.06)

0.39 (0.05,2.86)

0.52 (0.08,3.25)

0.49 (0.09,2.68)

  

 4.37 (0.90,21.24)

2.06 (0.18,23.11)

10.80 (1.08,108.39)

5.45 (0.40,74.41)

1.90 (0.55,6.59)

2.53 (0.96,6.69)

2.38 (1.19,4.75)

  

 21.37 (2.31,197.35)

L

5.24 (0.19,147.88)

2.64 (0.08,92.95)

0.92 (0.06,13.95)

1.23 (0.09,16.60)

1.15 (0.09,14.26)

  

 10.36   (0.39,276.40)

0.19 (0.01,5.39)

M

0.50 (0.11,2.27)

0.18 (0.01,2.41)

0.23 (0.02,2.86)

0.22 (0.02,2.45)

  

 1.98 (1.07,3.65)

0.38 (0.01,13.29)

1.98 (0.44,8.92)

N

0.35 (0.02,6.29)

0.46 (0.03,7.54)

0.44 (0.03,6.52)

  

 1.00 (0.42,2.39)

1.09 (0.07,16.48)

5.69 (0.41,78.28)

2.87 (0.16,51.98)

O

1.33 (0.27,6.48)

1.26 (0.30,5.22)

  

 3.92 (0.99,15.49)

0.82 (0.06,11.04)

4.27 (0.35,52.19)

2.16 (0.13,35.06)

0.75 (0.15,3.65)

P

0.94 (0.29,3.11)

  

 11.26 (0.88,143.99)

0.87 (0.07,10.69)

4.54 (0.41,50.37)

2.29 (0.15,34.19)

0.80 (0.19,3.31)

1.06 (0.32,3.50)

R

  
  1. A, CCRT (cisplatin + etoposide); B, CCRT (carboplatin + paclitaxel); C, CCRT (pemetrexed + carboplatin); CCRT Concurrent chemoradiotherapy, CI Confidence interval; D, CCRT (pemetrexed + cisplatin); E, CCRT (docetaxel + cisplatin); F, CCRT (S-1 + cisplatin); G, CCRT (mitomycin + vindesine + cisplatin); H, CCRT (cisplatin + vinorelbine); I, CCRT (cisplatin); K, RT; L, CCRT (5-FU); LA-NSCLC Locally advanced non-small cell lung cancer; N, CCRT (irinotecan + carboplatin); NMA Network meta-analysis; O, CCRT (nedaplatin); OR Odds radios; Q, CCRT (paclitaxel); ORR Objective response rate, OS Overall survival; R, CCRT (carboplatin)