Included studies | Comparisons | Efficacy events | Pairwise meta-analysis | |||
---|---|---|---|---|---|---|
Treatment 1 | Treatment 2 | OR (95% CI) | I2 | P | ||
ORR | ||||||
 3 studies | K VS. R | 84/174 | 95/176 | 0.80 (0.52–1.21) | 0.0% | 0.756 |
 2 studies | F VS. I | 34/56 | 29/56 | 1.44 (0.68–3.05) | 0.0% | 0.935 |
 2 studies | I VS. K | 99/173 | 92/176 | 1.22 (0.80–1.86) | 84.0% | 0.012 |
 1 study | A VS. B | 21/33 | 26/32 | 0.40 (0.13–1.26) | NA | NA |
 1 study | A VS. D | 90/272 | 102/283 | 0.88 (0.62–1.25) | NA | NA |
 1 study | A VS. E | 40/50 | 44/55 | 1.00 (0.38–2.61) | NA | NA |
 1 study | A VS. M | 70/95 | 62/96 | 1.54 (0.83–2.85) | NA | NA |
 1 study | B VS. G | 96/151 | 102/153 | 0.87 (0.54–1.40) | NA | NA |
 1 study | B VS. N | 96/151 | 86/152 | 1.34 (0.84–2.12) | NA | NA |
 1 study | C VS. D | 1/9 | 6/13 | 0.15 (0.01–1.53) | NA | NA |
 1 study | D VS. H | 46/52 | 44/48 | 0.70 (0.18–2.64) | NA | NA |
 1 study | E VS. G | 78/99 | 71/101 | 1.57 (0.82–2.99) | NA | NA |
 1 study | G VS. N | 102/153 | 86/152 | 1.53 (0.96–2.44) | NA | NA |
 1 study | F VS. H | 28/35 | 22/31 | 1.64 (0.53–5.09) | NA | NA |
 1 study | K VS. L | 16/101 | 29/99 | 0.45 (0.23–0.90) | NA | NA |
 1 study | K VS. O | 24/47 | 44/60 | 0.38 (0.17–0.85) | NA | NA |
 1 study | K VS. P | 56/66 | 60/65 | 0.47 (0.15–1.45) | NA | NA |
 1 study | K VS. Q | 14/20 | 18/21 | 0.39 (0.08–1.84) | NA | NA |
1-year OS rate | ||||||
 3 studies | K VS. R | 110/174 | 119/176 | 0.82 (0.53–1.28) | 0.0% | 0.962 |
 2 studies | A VS. B | 39/64 | 49/76 | 0.86 (0.43–1.71) | 72.4% | 0.057 |
 2 studies | F VS. I | 50/56 | 47/56 | 1.60 (0.53–4.83) | 0.0% | 0.995 |
 1 study | A VS. D | 209/272 | 215/283 | 1.05 (0.71–1.55) | NA | NA |
 1 study | A VS. E | 45/50 | 45/55 | 2.00 (0.63–6.32) | NA | NA |
 1 study | A VS. M | 71/95 | 77/96 | 0.73 (0.37–1.44) | NA | NA |
 1 study | B VS. G | 121/151 | 116/153 | 1.29 (0.75–2.22) | NA | NA |
 1 study | B VS. N | 121/151 | 114/152 | 1.34 (0.78–2.31) | NA | NA |
 1 study | D VS. H | 44/52 | 37/48 | 1.64 (0.60–4.49) | NA | NA |
 1 study | E VS. G | 17/99 | 32/101 | 0.45 (0.23–0.87) | NA | NA |
 1 study | G VS. N | 116/153 | 114/152 | 1.05 (0.62–1.76) | NA | NA |
 1 study | F VS. H | 27/35 | 23/31 | 1.17 (0.38–3.62) | NA | NA |
 1 study | I VS. K | 52/88 | 23/88 | 4.08 (2.16–7.72) | NA | NA |
 1 study | K VS. L | 26/101 | 26/99 | 0.97 (0.52–1.83) | NA | NA |
 1 study | K VS. O | 12/47 | 28/60 | 0.39 (0.17–0.90) | NA | NA |
 1 study | K VS. P | 45/66 | 48/65 | 0.76 (0.36–1.62) | NA | NA |
2-year OS rate | ||||||
 2 studies | A VS. B | 23/64 | 24/76 | 1.22 (0.60–2.46) | 71.4% | 0.061 |
 2 studies | K VS. R | 48/151 | 62/153 | 0.68 (0.43–1.10) | 16.7% | 0.273 |
 2 studies | F VS. I | 41/56 | 26/56 | 3.15 (1.43–6.96) | 0.0% | 0.854 |
 1 study | A VS. D | 141/272 | 147/283 | 1.00 (0.71–1.39) | NA | NA |
 1 study | A VS. E | 36/50 | 24/55 | 3.32 (1.47–7.51) | NA | NA |
 1 study | A VS. M | 46/95 | 41/96 | 1.26 (0.71–2.23) | NA | NA |
 1 study | B VS. G | 71/151 | 73/153 | 0.97 (0.62–1.53) | NA | NA |
 1 study | B VS. N | 71/151 | 61/152 | 1.32 (0.84–2.09) | NA | NA |
 1 study | D VS. H | 28/52 | 27/48 | 0.91 (0.41–2.00) | NA | NA |
 1 study | E VS. G | 39/99 | 52/101 | 0.61 (0.35–1.07) | NA | NA |
 1 study | F VS. H | 18/35 | 15/31 | 1.13 (0.43–2.97) | NA | NA |
 1 study | G VS. N | 73/153 | 61/152 | 1.36 (0.86–2.14) | NA | NA |
 1 study | I VS. K | 19/88 | 4/88 | 5.78 (1.88–17.80) | NA | NA |
 1 study | K VS. L | 4/101 | 9/99 | 0.42 (0.12–1.40) | NA | NA |
 1 study | K VS. O | 6/47 | 15/60 | 0.43 (0.15–1.21) | NA | NA |
 1 study | K VS. P | 17/66 | 28/65 | 0.46 (0.22–0.96) | NA | NA |
3-year OS rate | ||||||
 2 studies | F VS. I | 27/56 | 13/56 | 3.08 (1.37–6.94) | 0.0% | 0.921 |
 2 studies | K VS. R | 14/151 | 30/153 | 0.42 (0.21–0.83) | 0.0% | 0.412 |
 1 study | A VS. B | 11/33 | 4/32 | 3.50 (0.98–12.50) | NA | NA |
 1 study | A VS. D | 101/272 | 113/283 | 0.89 (0.63–1.25) | NA | NA |
 1 study | A VS. E | 29/50 | 17/55 | 3.09 (1.38–6.88) | NA | NA |
 1 study | A VS. M | 39/95 | 25/96 | 1.98 (1.07–3.65) | NA | NA |
 1 study | B VS. G | 40/151 | 54/153 | 0.66 (0.40–1.08) | NA | NA |
 1 study | B VS. N | 40/151 | 37/152 | 1.12 (0.67–1.88) | NA | NA |
 1 study | D VS. H | 23/52 | 15/48 | 1.74 (0.77–3.96) | NA | NA |
 1 study | E VS. G | 62/99 | 61/101 | 1.10 (0.62–1.94) | NA | NA |
 1 study | F VS. H | 12/35 | 10/31 | 1.10 (0.39–3.06) | NA | NA |
 1 study | G VS. N | 54/153 | 37/152 | 1.70 (1.03–2.79) | NA | NA |
 1 study | I VS. K | 9/88 | 2/88 | 4.90 (1.03–23.37) | NA | NA |
 1 study | K VS. L | 1/101 | 2/99 | 0.49 (0.04–5.44) | NA | NA |
 1 study | K VS. O | 4/47 | 9/60 | 0.53 (0.15–1.83) | NA | NA |
 1 study | K VS. P | 7/66 | 15/65 | 0.40 (0.15–1.05) | NA | NA |