Combined analysis of preoperative and postoperative lymphocyte-C-reactive protein ratio precisely predicts outcomes of patients with gastric cancer

Table 3 Univariate and multivariate analyses of prognostic factors for relapse-free survival in patients with gastric cancer

Variables	Univariate analysis			Multivariate analysis
	p value	HR^d	95% CI^e	p value	HR	95% CI
Age (≥ 75 vs. < 75)	0.0026	1.777	1.222–2.585	0.011	1.669	1.124–2.477
Gender (Male vs. Female)	0.092	1.483	0.937–2.347
Tumor size (≥ 4 vs. < 4)	0.003	1.759	1.212–2.553	0.495	1.156	0.763–1.750
Differentiation (Undifferentiated vs. Differentiated)^a	0.321	1.208	0.832–1.754
Depth of invasion (T2–4 vs. T1)^b	< 0.0001	2.536	1.741–3.694	0.453	1.220	0.726–2.051
Lymph node metastasis (Present vs. Absent)	< 0.0001	3.388	2.333–4.920	< 0.0001	2.757	1.756–4.329
Lymphatic involvement (Present vs. Absent)	< 0.0001	2.602	1.695–3.994	0.422	0.756	0.382–1.497
Venous involvement (Present vs. Absent)	< 0.0001	3.006	1.985–4.553	0.041	1.960	1.028–3.735
Postoperative complication (Present vs. Absent)^c	0.002	1.816	1.244–2.652	0.047	1.487	1.006–2.199
Combination of pre and postoperative LCR
pre- and post-LCR^L°^w vs. pre- or post-LCR^High	0.0001	2.474	1.566–3.906	0.0002	2.398	1.511–3.805
pre- and post-LCR^L°^w vs. pre- and post-LCR^High	< 0.0001	3.845	2.450–6.031	< 0.0001	3.120	1.961–4.965

^a Histology: Differentiated, papillary, or tubular adenocarcinoma; undifferentiated, poorly differentiated or mucinous adenocarcinoma, or signet ring cell carcinoma
^b Depth of invasion: T1, tumor invasion of the lamina propria or submucosa; T2, tumor invasion of the muscularis propria or subserosa; T3, tumor penetration of the serosa; T4, tumor invasion of adjacent organs
^c Postoperative complications were considered grade 2 or higher according to the Clavien–Dindo classification
^d HR Hazard ratio
^e CI Confidence interval

ISSN: 1471-2407