Combined analysis of preoperative and postoperative lymphocyte-C-reactive protein ratio precisely predicts outcomes of patients with gastric cancer

Table 2 Univariate and multivariate analyses of prognostic factors for overall survival in patients with gastric cancer

Variables	Univariate analysis			Multivariate analysis
	p value	HR ^d	95% CI ^e	p value	HR	95% CI
Age (≥ 75 vs. < 75)	0.0004	1.996	1.361–2.926	0.002	1.929	1.285–2.896
Gender (Male vs. Female)	0.100	1.489	0.931–2.381
Tumor size (≥ 4 vs. < 4)	0.0037	1.760	1.202–2.576	0.307	1.247	0.816–1.905
Differentiation (Undifferentiated vs. Differentiated)^a	0.393	1.181	0.806–1.730
Depth of invasion (T2–4 vs. T1)^b	< 0.0001	2.279	1.552–3.347	0.698	1.111	0.653–1.888
Lymph node metastasis (Present vs. Absent)	< 0.0001	2.897	1.978–4.244	0.0001	2.476	1.564–3.919
Lymphatic involvement (Present vs. Absent)	< 0.0001	2.458	1.587–3.807	0.518	0.793	0.393–1.601
Venous involvement (Present vs. Absent)	< 0.0001	2.814	1.844–4.297	0.058	1.908	0.978–3.723
Postoperative complications (Present vs. Absent)^c	0.002	1.844	1.251–2.717	0.072	1.446	0.967–2.163
Combination of pre and postoperative LCR
pre- and post-LCR^L°^w vs. pre- or post-LCR^High	< 0.0001	2.810	1.747–4.519	< 0.0001	2.781	1.719–4.496
pre- and post-LCR^L°^w vs. pre- and post-LCR^High	< 0.0001	3.831	2.434–6.031	< 0.0001	3.023	1.893–4.829

^a Histology: Differentiated, papillary, or tubular adenocarcinoma; undifferentiated, poorly differentiated or mucinous adenocarcinoma, or signet ring cell carcinoma
^b Depth of invasion: T1, tumor invasion of the lamina propria or submucosa; T2, tumor invasion of the muscularis propria or subserosa; T3, tumor penetration of the serosa; T4, tumor invasion of adjacent organs
^c Postoperative complications were considered grade 2 or higher according to the Clavien–Dindo classification
^d HR Hazard ratio
^e CI Confidence interval

ISSN: 1471-2407