Fig. 3

Kaplan–Meier survival estimates stratified by positive/negative DTC detection in bone marrow. A, C, E Progression-free survival and B, D, F overall survival estimates are shown for patients that showed positive (blue) or negative (orange) DTC detection in bone marrow samples acquired A-D before chemotherapy (BM1) or E and F during chemotherapy (BM2). DTC detection was based on all epithelial markers (A, B, E, F) or restricted to KRT7 and KRT8 mRNAs (C, D). P-values were calculated with log-rank tests; the numbers at risk are shown in the panels below each survival curve