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Table 4 Secondary outcomes chemotherapy-associated toxicity parameter list

From: Integrative medicine during the intensive phase of chemotherapy in pediatric oncology in Germany: a randomized controlled trial with 5-year follow up

Secondary outcome parameter:

Neutrophil granulocytes

Neutropenia, number of days

Red blood cell transfusion

Transfusion of thrombocyte concentrates

Fever, maximum temperature

Antibiotics

Antimycotics/antifungals

Catheter infection

Number of C-reactive protein values/measurements above the norm

Number of C-reactive protein

Values threefold above the norm

Maximum CRP value

Days with fever above 38,5 °C

Nausea

Emesis

Stomatitis

Number of days with stomatitis

Abdominal pain/cramping

Gastritis

Obstipation

Diarrhea episodes per day

Pancreas ultrasonography/sonography

Thrombosis

Creatinine clearance

Steroid diabetes

Cushing syndrome

Arrhythmia

Cardiac function

Echocardiography, left ventricular shortening fraction

Pain

Central neurotoxicity

Fatigue

Peripheral neurotoxicity

Mood swings: depression

Mood swings: anxiety

Mood swings: euphoria

General wellbeing

Skin alterations

Osteonecrosis

Delay in onset of the last treatment block

Hemoglobin

Thrombocytes

Leucocytes maximum value

Leucocytes minimum value

CRP maximum value

Alpha lipase

Glucose

Aspartat amino transferase (AST, ASAT)

Alanin amino transferase (ALT, ALAT)

Bilirubin

Creatinine

Amylase

Fibrinogen

Antithrombin III (AT-III)

Proteinuria

prothrombin time (PTT)