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Fig. 5 | BMC Cancer

Fig. 5

From: Interfering with the expression of EEF1D gene enhances the sensitivity of ovarian cancer cells to cisplatin

Fig. 5

Reducing the expression of EEF1D gene regulated the contents and/or activities of proteins associated with PI3K/Akt signaling pathway, apoptosis and repair of DNA damage in xenografted tumor. A The related proteins in xenografted tumor tissues were detected with Western blotting, and β-actin was used to show the similar amount of protein loaded in different lanes. B, D Relative intensities of protein bands in A were determined using Quantity-One software and normalized using β-actin band intensity. C Akt phosphorylation levels were calculated according to the relative intensities of p-Akt/Akt bands, normalized using β-actin. Data in B, C and D are presented as mean ± SD of six mice in each group. * P < 0.05, ** P < 0.01 vs. control; # P < 0.05, ## P < 0.01 vs. DDP group

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