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Table 3 Comparison of the new prognostic model with conventional models for stratifying survival outcomes in the training and validation cohorts

From: Enhancement of the International prognostic index with β2-microglobulin, platelet count and red blood cell distribution width: a new prognostic model for diffuse large B-cell lymphoma in the rituximab era

Risk group (score)

Training cohort (n = 701)

Validation cohort (n = 297)

n (%)

5-y PFS, % (95%CI)

5-y OS,% (95%CI)

n (%)

5-y PFS, % (95%CI)

5-y OS, % (95%CI)

New model

 Low (0)

285 (40.7)

84.0 (79.8–88.4)

90.9 (87.6–94.7)

118 (39.7)

87.2 (81.3–93.5)

91.2 (86.2–96.6)

 Low-intermediate (1)

85 (12.1)

72.1 (62.9–82.5)

80.4 (72.2–89.5)

38 (12.8)

68.0 (54.5–84.8)

77.8 (65.3–92.8)

 High-intermediate (2–3)

176 (25.1)

55.7 (48.8–63.6)

66.7 (59.9–74.3)

89 (30.0)

56.7 (47.3–68.1)

65.6 (56.3–76.4)

 High (4)

53 (7.6)

33.7 (23.0–49.2)

49.1 (36.9–65.2)

22 (7.4)

36.4 (20.9–63.2)

47.7 (30.5–74.7)

 Very High (≥5)

102 (14.6)

19.0 (12.5–29.1)

29.7 (21.7–40.6)

30 (10.1)

23.3 (12.2–44.6)

26.7 (14.7–48.3)

IPI

 Low (0–1)

390 (55.6)

80.0 (76.1–84.1)

87.2 (83.9–90.7)

162 (54.5)

80.5 (74.6–86.9)

87.1 (82.0–92.6)

 Low-intermediate (2)

131 (18.7)

55.3 (47.3–64.5)

64.1 (56.2–73.1)

72 (24.2)

56.9 (46.5–69.6)

64.7 (54.5–76.9)

 High-intermediate (3)

116 (16.5)

33.7 (26.0–43.7)

50.0 (41.4–60.3)

40 (13.5)

47.5 (34.3–65.8)

55.0 (41.6–72.8)

 High (4–5)

64 (9.1)

20.6 (12.4–34.3)

30.1 (20.3–44.6)

23 (7.7)

17.4 (7.1–42.4)

21.7 (10.0–47.2)

R-IPI

 Very good (0)

174 (24.8)

87.1 (82.2–92.3)

92.6 (88.7–96.7)

77 (25.9)

81.7 (73.4–90.8)

86.5 (79.0–94.7)

 Good (1–2)

347 (49.5)

67.1 (62.3–72.2)

75.8 (71.4–80.6)

157 (52.9)

69.1 (62.2–76.8)

77.2 (70.8–84.1)

 Poor (≥3)

180 (25.7)

29.1 (23.1–36.8)

42.8 (35.9–51.1)

63 (21.2)

36.5 (26.4–50.6)

42.9 (32.2–57.0)

NCCN-IPI

 Low (0–1)

221 (31.5)

85.3 (80.7–90.1)

91.5 (87.8–95.3)

95 (32.0)

80.8 (73.3–89.2)

85.9 (79.0–93.3)

 Low-intermediate (2–3)

313 (44.7)

63.8 (58.6–69.4)

71.9 (66.9–77.1)

143 (48.1)

67.5 (60.2–75.7)

75.7 (69.0–83.2)

 High-intermediate (4–5)

146 (20.8)

31.5 (24.7–40.1)

49.0 (41.3–58.3)

53 (17.8)

37.6 (26.5–53.2)

44.0 (32.4–59.9)

 High (≥6)

21 (3.0)

9.4 (1.7–51.1)

11.9 (3.4–41.3)

6 (2.0)

16.7 (2.8–99.7)

16.7 (2.8–99.7)

  1. Abbreviations: PFS Progression-free survival, OS Overall survival, 5-y 5-year, CI Confidence interval, IPI International Prognostic Index, R-IPI Revised International Prognostic Index, NCCN-IPI National Comprehensive Cancer Network International Prognostic Index