Risk group (score) | Training cohort (n = 701) | Validation cohort (n = 297) | ||||
---|---|---|---|---|---|---|
n (%) | 5-y PFS, % (95%CI) | 5-y OS,% (95%CI) | n (%) | 5-y PFS, % (95%CI) | 5-y OS, % (95%CI) | |
New model | ||||||
Low (0) | 285 (40.7) | 84.0 (79.8–88.4) | 90.9 (87.6–94.7) | 118 (39.7) | 87.2 (81.3–93.5) | 91.2 (86.2–96.6) |
Low-intermediate (1) | 85 (12.1) | 72.1 (62.9–82.5) | 80.4 (72.2–89.5) | 38 (12.8) | 68.0 (54.5–84.8) | 77.8 (65.3–92.8) |
High-intermediate (2–3) | 176 (25.1) | 55.7 (48.8–63.6) | 66.7 (59.9–74.3) | 89 (30.0) | 56.7 (47.3–68.1) | 65.6 (56.3–76.4) |
High (4) | 53 (7.6) | 33.7 (23.0–49.2) | 49.1 (36.9–65.2) | 22 (7.4) | 36.4 (20.9–63.2) | 47.7 (30.5–74.7) |
Very High (≥5) | 102 (14.6) | 19.0 (12.5–29.1) | 29.7 (21.7–40.6) | 30 (10.1) | 23.3 (12.2–44.6) | 26.7 (14.7–48.3) |
IPI | ||||||
Low (0–1) | 390 (55.6) | 80.0 (76.1–84.1) | 87.2 (83.9–90.7) | 162 (54.5) | 80.5 (74.6–86.9) | 87.1 (82.0–92.6) |
Low-intermediate (2) | 131 (18.7) | 55.3 (47.3–64.5) | 64.1 (56.2–73.1) | 72 (24.2) | 56.9 (46.5–69.6) | 64.7 (54.5–76.9) |
High-intermediate (3) | 116 (16.5) | 33.7 (26.0–43.7) | 50.0 (41.4–60.3) | 40 (13.5) | 47.5 (34.3–65.8) | 55.0 (41.6–72.8) |
High (4–5) | 64 (9.1) | 20.6 (12.4–34.3) | 30.1 (20.3–44.6) | 23 (7.7) | 17.4 (7.1–42.4) | 21.7 (10.0–47.2) |
R-IPI | ||||||
Very good (0) | 174 (24.8) | 87.1 (82.2–92.3) | 92.6 (88.7–96.7) | 77 (25.9) | 81.7 (73.4–90.8) | 86.5 (79.0–94.7) |
Good (1–2) | 347 (49.5) | 67.1 (62.3–72.2) | 75.8 (71.4–80.6) | 157 (52.9) | 69.1 (62.2–76.8) | 77.2 (70.8–84.1) |
Poor (≥3) | 180 (25.7) | 29.1 (23.1–36.8) | 42.8 (35.9–51.1) | 63 (21.2) | 36.5 (26.4–50.6) | 42.9 (32.2–57.0) |
NCCN-IPI | ||||||
Low (0–1) | 221 (31.5) | 85.3 (80.7–90.1) | 91.5 (87.8–95.3) | 95 (32.0) | 80.8 (73.3–89.2) | 85.9 (79.0–93.3) |
Low-intermediate (2–3) | 313 (44.7) | 63.8 (58.6–69.4) | 71.9 (66.9–77.1) | 143 (48.1) | 67.5 (60.2–75.7) | 75.7 (69.0–83.2) |
High-intermediate (4–5) | 146 (20.8) | 31.5 (24.7–40.1) | 49.0 (41.3–58.3) | 53 (17.8) | 37.6 (26.5–53.2) | 44.0 (32.4–59.9) |
High (≥6) | 21 (3.0) | 9.4 (1.7–51.1) | 11.9 (3.4–41.3) | 6 (2.0) | 16.7 (2.8–99.7) | 16.7 (2.8–99.7) |