Table 2 Metabolic pathway enrichment
From: Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer
Upregulated | Downregulated | |
|---|---|---|
Transcriptional misregulation in cancer | Cytokine-cytokine receptor interaction | Tuberculosis |
ABC transporters | NOD-like receptor signaling pathway | Axon guidance |
Alcoholism | Lipid and atherosclerosis | Calcium signaling pathway |
Axon guidance | Amoebiasis | Phospholipase D signaling pathway |
Viral carcinogenesis | TNF signaling pathway | Cholinergic synapse |
Cell adhesion molecules | Influenza A | Wnt signaling pathway |
Rap1 signaling pathway | JAK-STAT signaling pathway | cGMP-PKG signaling pathway |
Neutrophil extracellular trap formation | Rheumatoid arthritis | Leishmaniasis |
Fluid shear stress and atherosclerosis | Hematopoietic cell lineage | Complement and coagulation cascades |
Necroptosis | IL-17 signaling pathway | Toxoplasmosis |
Systemic lupus erythematosus | AGE-RAGE signaling pathway in diabetic complications | ECM-receptor interaction |
Glycerolipid metabolism | Pertussis | Morphine addiction |
Platelet activation | Inflammatory bowel disease | Inflammatory mediator regulation of TRP channels |
Parathyroid hormone synthesis, secretion and action | C-type lectin receptor signaling pathway | Melanogenesis |
Ferroptosis | Legionellosis | HIF-1 signaling pathway |
Aldosterone synthesis and secretion | NF-kappa B signaling pathway | Relaxin signaling pathway |
PPAR signaling pathway | Toll-like receptor signaling pathway | Natural killer cell mediated cytotoxicity |
TGF-beta signaling pathway | Chagas disease | Vascular smooth muscle contraction |
Osteoclast differentiation | Gastric acid secretion | Fluid shear stress and atherosclerosis |
Estrogen signaling pathway | Viral protein interaction with cytokine and cytokine receptor | RIG-I-like receptor signaling pathway |
Inflammatory mediator regulation of TRP channels | Cytosolic DNA-sensing pathway | Leukocyte transendothelial migration |
Steroid hormone biosynthesis | African trypanosomiasis | Bladder cancer |
Circadian entrainment | Malaria | Arachidonic acid metabolism |
Cholinergic synapse | Melanoma | Basal cell carcinoma |
Amphetamine addiction | Pathways in cancer | Drug metabolism |
Ovarian steroidogenesis | PI3K-Akt signaling pathway | Insulin secretion |
Prostate cancer | MAPK signaling pathway | Staphylococcus aureus infection |
Regulation of lipolysis in adipocytes | Human cytomegalovirus infection | Aldosterone synthesis and secretion |
Cortisol synthesis and secretion | Human papillomavirus infection | Regulation of lipolysis in adipocytes |
Retinol metabolism | Coronavirus disease | Glycerolipid metabolism |
Adherens junction | Human immunodeficiency virus 1 infection | Long-term potentiation |
| Â | Hepatitis B | Renin secretion |
| Â | Rap1 signaling pathway | Glioma |