Fig. 5
From: Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer
A. Homology modelling of PTPRC, MUC19, KCNB1, TAGLN and KISS1 protein. The optimized conformations of five downregulated protein structures represented as cartoon models. The reactive binding domains were constructed for MUC19 and KISS1 proteins due to the lack of template availability. B. Molecular docking of JQ1 and GSK2801 against PTPRC, MUC19, KCNB1, TAGLN and KISS1 proteins. Binding mode orientation of JQ1 (Pink) and GSK2801 (Cyan) with downregulated proteins in TNBC. The ligands are shown in the binding site cavities of target proteins