Fig. 6
From: YAP1 is essential for malignant mesothelioma tumor maintenance
In vivo pharmacodynamic analysis of MSTO-211H-SH-YAP1 xenografts: A In this pharmacodynamic study, tumors were allowed to growth up to 300 mm.3 under glucose supplementation and were sampled just before doxycycline supplementation (time point 1, n = 5), 24 h (n = 5), 96 h (n = 5) and 216 h (n = 4) post doxycycline supplementation (time point 2 & 3) and 96 h post doxycycline induction followed by 6 days without doxycycline supplementation (time point 4). B mRNA expression by RT-qPCR. C TEAD-dependent transcription (deR)