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Fig. 3 | BMC Cancer

Fig. 3

From: Significance of tumor heterogeneity of p-Smad2 and c-Met in HER2-positive gastric carcinoma with lymph node metastasis

Fig. 3

A representative gastric cancer case with intra-tumoral heterogeneity. A Hematoxylin and eosin (H&E) staining. Histologic intra-tumoral heterogeneity is shown. Arrows: poorly-differentiated cancer cells, arrowheads: well-differentiated cancer cells. B Intra-tumoral heterogeneity of HER2. Arrowheads: HER2-positive, arrows: HER2-negative. In this case, the HER2 expression was dependent on the differentiation level of the gastric cancer. The well-differentiated gastric cancer cells showed HER2-positive expression, while the poorly-differentiated cancer cells were HER2-negative (A-1, A-2, B-1, B-2). The well-differentiated cancer cells showed different HER2-positive expression levels (A-3, B-3)

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BMC Cancer

ISSN: 1471-2407

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