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Fig. 2 | BMC Cancer

Fig. 2

From: HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells

Fig. 2

Effect of rHMGB1 on breast cancer cell invasion in a 3-D tumor spheroid-based invasion assay. MDA-MB-231 P cell invasions at 96 h from the tumor spheroid after 100 ng/ml rHMGB1 treatment (a and c) and MDA-MB-231 BM (b and d). Representative bright-field images of cell migration at 0 h and 96 h are shown. Graphs represent percent cell invasion of control unstimulated cells (0.1% BSA DMEM). Bars represent mean ± SD of duplicate independent experiments. *P < 0.05

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BMC Cancer

ISSN: 1471-2407

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