Table 2 NOSTRIN-induced alteration of transcripts associated with epithelial mesenchymal transition in HCT116 cells
Sl No. | Gene symbol | Accession No. | Mean Ct Control | Mean Ct NOSTRIN | Fold change | Gene description |
|---|---|---|---|---|---|---|
1 | COL3A1 | NM_000090 | 22.60 | 25.36 | -8.2861 | Collagen, type III, alpha 1 |
2 | F11R | NM_016946 | 26.56 | 29.08 | -7.0037 | F11 receptor |
3 | CAV2 | NM_001233 | 26.46 | 28.64 | -5.5639 | Caveolin 2 |
4 | FGFBP1 | NM_005130 | 26.63 | 28.64 | -4.9563 | Fibroblast growth factor binding protein 1 |
5 | FN1 | NM_002026 | 26.83 | 28.63 | -4.286 | Fibronectin 1 |
6 | PTK2 | NM_005607 | 24.69 | 26.46 | -4.1783 | PTK2 protein tyrosine kinase 2 |
7 | MSN | NM_002444 | 25.31 | 26.93 | -3.7788 | Moesin |
8 | CTNNB1 | NM_001904 | 25.11 | 26.73 | -3.7641 | Catenin (cadherin-associated protein), beta 1 |
9 | VIM | NM_003380 | 26.83 | 28.29 | -3.3633 | Vimentin |
10 | TGFB1 | NM_000660 | 26.54 | 27.96 | -3.2979 | Transforming growth factor, beta 1 |
11 | TIMP1 | NM_003254 | 25.99 | 27.38 | -3.2095 | TIMP metallopeptidase inhibitor 1 |
12 | BMP1 | NM_006129 | 27.88 | 29.26 | -3.1974 | Bone morphogenetic protein 1 |
13 | SMAD2 | NM_005901 | 24.23 | 25.60 | -3.1776 | SMAD family member 2 |
14 | RGS2 | NM_002923 | 23.02 | 24.35 | -3.0905 | Regulator of G-protein signaling 2 |
15 | SNAI2 | NM_003068 | 29.77 | 27.95 | -2.8814 | Snail homolog 2 (Drosophila) |
16 | BMP7 | NM_001719 | 28.59 | 29.81 | -2.846 | Bone morphogenetic protein 7 |
17 | ILK1 | NM_004517 | 25.50 | 26.69 | -2.7951 | Integrin-linked kinase |
18 | COL5A2 | NM_000393 | 27.79 | 28.97 | -2.778 | Collagen, type V, alpha 2 |
19 | CALD1 | NM_004342 | 25.13 | 26.28 | -2.7295 | Caldesmon 1 |
20 | OCLN | NM_002538 | 23.79 | 24.94 | -2.7118 | Occludin |
21 | ERBB3 | NM_001982 | 27.5 | 28.61 | -2.6688 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
22 | AHNAK | NM_024060 | 28.28 | 29.38 | -2.6367 | AHNAK nucleoprotein |
23 | MAP1B | NM_005909 | 26.82 | 27.91 | -2.61 | Microtubule-associated protein 1B |
24 | ITGAV | NM_002210 | 25.71 | 26.78 | -2.5859 | Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) |
25 | JAG1 | NM_000214 | 26.34 | 27.41 | -2.567 | Jagged 1 |
26 | DSC2 | NM_004949 | 26.8 | 27.78 | -2.4298 | Desmocollin 2 |
27 | KRT19 | NM_002276 | 19.42 | 20.38 | -2.3906 | Keratin 19 |
28 | STAT3 | NM_003150 | 24.57 | 25.53 | -2.3831 | Signal transducer and activator of transcription 3 (acute-phase response factor) |
29 | NUDT13 | NM_015901 | 28.44 | 29.38 | -2.3525 | Nudix (nucleoside diphosphate linked moiety X)-type motif 13 |
30 | ITGα5 | NM_002205 | 26.88 | 27.768 | -2.2717 | Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
31 | DSP | NM_004415 | 23.9 | 24.74 | -2.2066 | Desmoplakin |
32 | VCAN | NM_004385 | 24.34 | 25.10 | -2.0792 | Versican |
33 | CDH1 | NM_004360 | 27.63 | 25.73 | 4.5952 | Cadherin 1, type 1, E-cadherin (epithelial) |