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Fig. 1 | BMC Cancer

Fig. 1

From: Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort

Fig. 1

Sample composition for model training, development, evaluation, and exploratory sets by HRR mutation status and cancer type. A HRD-DNA. B HRD-RNA. To train, develop and evaluate the HRD-DNA and HRD-RNA models, BRCA1/2 biallelic loss and HRR-WT samples were randomized into the training, development and evaluation sets, while samples with BRCA1/2 monoallelic loss or HRR alterations (monoallelic or biallelic) in a select number of genes, were assigned to the exploratory set. Samples in the evaluation set were used to test final model performance. Samples in the exploratory set were used to determine overall rates of samples called HRD+ and enrichment of HRR mutations in HRD+ calls. Development sets were only utilized in the HRD-RNA test. Percentages were calculated as a function of the total samples in each cancer cohort for each test

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