Fig. 7
From: Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells
Schematic representation of the proposed model. On the left in red is represented the CRC cell treated with the chemotherapeutic drug 5-Fluorouracil (5-FU) which in normoxic conditions activates the apoptotic process. In blue at the top right is represented the CRC cell treated with 5-FU in conditions of prolonged hypoxia, in which the overexpression of miR-675-5p inhibits the activation of the apoptotic process by targeting the pro-caspase 3. Finally, below on the right in blue is represented the CRC cell treated with 5-FU in conditions of prolonged hypoxia, in which the presence of AntagomiR-675-5p activates the apoptotic process, increasing the protein levels of the cleaved caspase-3 and the cleaved PARP