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Fig. 4 | BMC Cancer

Fig. 4

From: Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells

Fig. 4

Effects of AntagomiR-675-5p treatment on apoptosis markers. A-B: Representative images and densitometric analysis of Western blots for cleaved PARP/PARP and Cleaved caspase-3 obtained from protein lysates of HCT116 and SW480 in chronic hypoxia, transfected with AntagomiR-675-5p or Scrambled Negative Control (Scr) and treated or not with 5-FU (10 μM). The graphs ordinate shows the OD (Optical Density) of the indicated proteins normalized for the housekeeping’s OD (β-actin). Data are expressed as the mean ± SD of three independent experiments and statistical significance was analyzed by using Ordinary one-way ANOVA with Bonferroni’s multiple comparison test (* = p < 0.05; ** = p < 0.01; *** = p < 0.001; **** = p < 0.0001). Corresponding uncropped full-length blots are included in a Supplementary Material

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