Parameters (CV%) | 60 mg (n = 12) | 200 mg (n = 12) | 400 mg (n = 12) |
---|---|---|---|
Cmax (ug/ml) mean ± SD, (%CV) | 19.93 ± 4.21 (21.1) | 73.93 ± 11.09 (15.0) | 139.69 ± 23.49 (16.8) |
Tmax (hours), median (range) | 0.73 (0.63, 48.42) | 0.71 (0.65, 24.65) | 0.78 (0.65, 6.72) |
AUC0-t (day·ug/ml), median (%CV) | 68.77 (38.8) | 400.69 (22.5) | 1044.37 (18.9) |
AUC0-inf (day·ug/ml), median (%CV) | 68.46 (39.2) | 452.31 (27.8) | 1285.45 (23.6) |
t1/2, day, median (%CV) | 3.06 (31.1) | 5.92 (27.8) | 12.22 (25.8) |
Rac,cmax, median (%CV) | 1.11 (21.4) | 1.50 (7.3) | 1.37 (10.3) |