Fig. 9

Landscape of somatic mutation profiles in low−/high-risk samples. A A word cloud generated based on frequency of mutated genes in low-risk subgroup. The size of each gene is proportional to the total number of samples mutated / altered. B Cohort summary plot of low-risk subgroup displaying distribution of variants according to variant classification, type and SNV class. Bottom part (from left to right) indicates mutation load for each sample, variant classification type. A stacked barplot shows top ten mutated genes. C Transition and transversion plot displaying distribution of SNVs in low-risk subgroup classified into six transition and transversion events. Stacked bar plot (bottom) shows distribution of mutation spectra for every sample in the MAF file. D A word cloud generated based on frequency of mutated genes in high-risk subgroup. The size of each gene is proportional to the total number of samples mutated / altered. E Cohort summary plot of high-risk subgroup displaying distribution of variants according to variant classification, type and SNV class. Bottom part (from left to right) indicates mutation load for each sample, variant classification type. A stacked barplot shows top ten mutated genes. F Transition and transversion plot displaying distribution of SNVs in high-risk subgroup classified into six transition and transversion events. Stacked bar plot (bottom) shows distribution of mutation spectra for every sample in the MAF file