Table 2 Comparison of newly derived EORTC QLQ-C30 reference values for metastatic pancreatic cancer, baseline QLQ-C30 POLO scores, and QLQ-C30 general population norm data
EORTC QLQ-C30 Scale | Newly derived mPC reference values | Baseline POLO scores (n = 147) | General population norm data1 | Difference2 (POLO vs. mPC reference values) | Difference2 (mPC reference values vs norm data) | Difference2 (POLO vs. general population norm data) | |
|---|---|---|---|---|---|---|---|
n | Mean | Mean | Mean | Mean difference | Mean difference | Mean difference | |
Global health status/QoL | 629 | 54.3 | 71.9 | 66.1 | 17.6 | −11.8 | 5.8 |
Functional scales | |||||||
Physical functioning | 639 | 78.2 | 83.9 | 85.1 | 5.8 | −6.9 | −1.2 |
Role functioning | 473 | 62.5 | 78.1 | 84.3 | 15.6 | −21.8 | −6.2 |
Emotional functioning | 638 | 65.9 | 81.4 | 74.2 | 15.5 | −8.3 | 7.2 |
Cognitive functioning | 473 | 81.5 | 85.5 | 84.8 | 4.0 | −3.3 | 0.7 |
Social functioning | 469 | 70.2 | 76.8 | 86.2 | 6.6 | −16.0 | −9.4 |
Symptom scales | |||||||
Fatigue | 639 | 46.0 | 29.5 | 29.5 | −16.5 | 16.5 | −0.0 |
Nausea and vomiting | 476 | 16.2 | 8.3 | 5.9 | −7.9 | 10.3 | 2.4 |
Pain | 639 | 41.9 | 16.6 | 23.5 | − 25.3 | 18.4 | −7.0 |
Dyspnea | 475 | 19.4 | 10.0 | 15.9 | −9.4 | 3.5 | −5.9 |
Insomnia | 476 | 41.6 | 23.1 | 26.6 | −18.5 | 15.0 | −3.5 |
Appetite loss | 476 | 44.6 | 14.7 | 10.0 | −29.9 | 34.6 | 4.7 |
Constipation | 473 | 32.7 | 13.4 | 12.5 | −19.3 | 20.2 | 0.9 |
Diarrhea | 469 | 13.5 | 15.5 | 9.5 | 2.0 | 4.0 | 6.0 |
Financial difficulties | 466 | 15.7 | 19.3 | 10.6 | 3.6 | 5.1 | 8.7 |