Fig. 2

Significant mRNA expression alterations of folate receptors and genes involved in one-carbon cycle. On the heatmap, distinct colours are coupled to different expression intensity values: green - low, black - intermediate, red - high intensity. Each row represents different genes, and each column indicates the investigated sample types. Only candidates owning significant expression changes (p ≤ 0.05) and fold change value greater or equal than |1.4| in both AD and CRC tissue samples compared to N were presented on the heatmap. One-carbon metabolism-related enzymes showed significantly elevated mRNA expression in AD and CRC samples compared to N. FOLR2 had a significantly lower transcript level in tumorous samples vs. healthy controls (p ≤ 0.05). N: healthy, AD: colorectal adenoma, CRC: colorectal carcinoma