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Table 6 Univariate and multivariate Cox regression analysis of prognostic value of clinicopathological factors on tumor distant metastasis-free survival (DMFS)

From: Prognostic significance of different molecular typing methods and immune status based on RNA sequencing in HR-positive and HER2-negative early-stage breast cancer

Variable (DMFS)

Univariate cox regression analysis

Multivariate cox regression analysis

HR (95%CI)

P

HR (95%CI)

P

Age at diagnosis

 

0.446

0.540(0.136–2.144)

0.381

≦50

1

   

 > 50

0.659 (0.225–1.928)

   

Tumor size

 

0.152

3.188(0.716–14.205)

0.128

≦1 cm

1

   

 > 1 cm

2.527 (0.712–8.970)

   

Histological grade

 

0.988

0.895(0.118–6.793)

0.915

I/II

1

   

III

1.011 (0.228–4.483)

   

Ki-67 index

 

0.904

0.472(0.025–8.760)

0.614

≦30

1

   

 > 30

1.081 (0.305–3.834)

   

P53

 

0.528

1.006(0.206–4.913)

0.994

Positive

1

   

Negative

1.447 (0.459–4.562)

   

Basal-like marker

 

0.022*

5.529(1.196–25.560)

0.029*

Negative

1

   

Positive

3.534 (1.202–10.388)

   

Modified IHC subtype

 

0.253

0.378(0.074–1.938)

0.244

Basal-like

1

   

Luminal A

0.342(0.096–1.218)

0.098

  

Luminal B

0.000(0.000–1.734E + 229)

0.960

  

PAM50 subtype

 

0.215

1.831(0.493–6.802)

0.366

Basal-like

1

   

Luminal A

0.270(0.074–0.986)

0.055

  

Luminal B

0.209(0.035–1.252)

0.762

  

Her-2 enriched

0.000(0.000-)

0.289

  

ROR

 

0.077

1.542(0.425–5.592)

0.510

High

1

   

Medium

0.213 (0.050–0.900)

0.035

  

Low

0.245 (0.063–0.958)

0.043

  

RS

 

0.634

0.639(0.186–2.190)

0.476

High

1

   

Medium

0.492 (0.082–2.949)

0.346

  

Low

0.482 (0.105–2.202)

0.438

  

TILs

 

0.026*

1.801(0.390–8.311)

0.451

Low

1

   

High

3.385 (1.157–9.905)

   

Immune score

 

0.051

4.551(0.913–22.699)

0.065

i-weak

1

   

i-strong

2.752 (0.997–7.592)

   

Chemotherapy

 

0.121

1.678(0.454–6.197)

0.437

Negative

1

   

Positive

2.235 (0.809–6.171)

 

Radiotherapy

 

0.247

0.829(0.243–2.825)

0.764

Negative

1

   

Positive

1.842(0.654–5.183)

   
  1. *P < 0.05