Fig. 1

Disease-specific survival (DSS) probability correlated with Estimate scores, and screening of differentially expressed genes as well as functional enrichment. A Comparison of the DSS rate between the high or low ImmuneScore groups in EC (P = 0.029, n = 541). B DSS for EC patients with high or low StromalScore (P = 0.436, n = 541). C Comparison of the DSS rate between the high or low ESTIMATEScore groups in EC by log-rank test (P = 0.361, n = 541). D The top 50 differentially expressed genes of EC grouped by ImmuneScore, displayed by heatmap. Rownames represented the gene names, the clustering characteristics of which were analyzed according to the expression patterns of DEGs. E Heatmap of the top 50 differentially expressed genes generated by comparison between high or low StromalScore groups, with FDR < 0.05 and |log FC| > 1. The color stood for the expression level of DEGs. F, G Genes shared by ImmuneScore and StromalScore, displayed by Venn plots (Upper panel for the up-regulated genes and lower panel for the down-regulated ones). H Bar plots for the top 10 enriched terms of biological process, cellular component, and molecular function of 386 DEGs in GO enrichment, respectively, where q value < 0.05 were regarded to be enriched significantly. I Circos plot for functional classification of KEGG with the identified categories displayed, the KEGG pathway database is granted by Kanehisa laboratories [26]