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Fig. 4 | BMC Cancer

Fig. 4

From: PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment

Fig. 4

The ectopic expression of hPARG in 3 T3 cells changes the expression profile of genes implicated in tumorigenesis, specifically chemokines. A A volcano plot depicting RNA-seq results for fold change of gene expression in cells expressing hPARG vs non-induced control (no doxycycline). Each point represents the average fold change of one gene for three biological replicates of hPARG-expressing cells relative to control. Genes are colored and labeled if they pass the significance value of log2(fold change) > 1 with an FDR corrected P-value < 0.05. Upregulated genes are colored red (Up) and annotated with red boxes; downregulated genes (Down) are colored blue and annotated with blue boxes; genes, for which expression level demonstrated no significant change (Not Sig), are represented by unannotated gray dots. B Heat map depicting RNA-seq results of expression levels for differentially expressed genes in cells expressing hPARG vs control. Expression levels for each of the three biological replicates from both treatment groups (hPARG vs control) are shown on the X-axis with the corresponding gene names on the Y-axis

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