Table 5 The most reported potential drug-drug interactions

Paracetamol/Ondansetron

90

B

Ondansetron diminish the analgesic effect of Paracetamol

Cyclophosphamide/Ondansetron

74

B

Ondansetron may decrease the serum concentration of cyclophosphamide

Doxorubicin/Cyclophosphamide

61

C

Cyclophosphamide may enhance the cardiotoxic effect of Anthracyclines

Metformin/Dexamethasone

54

C

Dexamethasone may diminish the therapeutic effect of Metformin

Dexamethasone/Aspirin

44

C

Salicylates may enhance the adverse/toxic effect of corticosteroids. These specifically include GI ulceration and bleeding. Corticosteroids may decrease the serum concentration of salicylates. Withdrawal of corticosteroids may result in salicylate toxicity