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Fig. 4 | BMC Cancer

Fig. 4

From: A stratification model of hepatocellular carcinoma based on expression profiles of cells in the tumor microenvironment

Fig. 4

Identification of signature genes of three tumor microenvironment (TME) subtypes and functional annotation. a Volcano plots of the differentially expressed genes between C1 and C2, between C2 and C3, and between C1 and C3, respectively. b Diagram depicting the process of identification of the signature genes of three TME subtypes. c Venn diagram showing the signature genes of three TME subtypes with no duplication. d Three different subtypes of signature genes shown as a heatmap. Abbreviation: FPKM, fragments per kilobase of exon per million reads mapped. e Bubble plots of Kyoto Encyclopedia of Genes and Genomes pathway analysis of TME subtypes’ signature genes

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