Fig. 3

Clinical characteristics of different TME subtypes. a Heatmap describing the absolute abundance of tumor microenvironment (TME) cell populations in TME subtypes C1, C2, and C3. Group information; mutation status of TP53, CTNNB1, and FGF19; vascular invasion; American Joint Committee on Cancer stage; histological grade; and gender are shown as patient annotations. b Boxplot of the tumor mutation burden in three TME subtypes. The differences were compared by using the Mann–Whitney U test. c Violin plot of the absolute abundance of TME cell populations between the low-TMB and high-TMB groups distinguished by median value. The differences between each subtype were compared using Student’s t-test