|
Variables
|
Univariable logistic regressionsa
|
Multivariable logistic regressionsb
|
|---|
|
Effect estimate
|
OR (odds ratio)
|
P value
|
Effect estimate
|
Standard error
|
OR
|
P value
|
|---|
|
Smoking
|
|
Current
|
−0.726
|
0.484
|
0.393
| | | | |
|
Former
|
0.250
|
1.283
|
0.652
| | | | |
|
None
|
ref
| | | | | | |
|
Caffeine
|
−0.0013
|
0.999
|
0.449
| | | | |
|
Age of menarche
|
|
> 12
|
−0.475
|
0.622
|
0.334
| | | | |
|
≤ 12
|
ref
| | | | | | |
|
Breastfeedcd
|
0.765
|
2.148
|
0.066
|
0.899
|
0.402
|
2.457
|
0.026
|
|
OCP duration
|
|
10+ years
|
−0.123
|
0.884
|
0.876
| | | | |
|
5–10 years
|
−0.329
|
0.720
|
0.499
| | | | |
|
2–5 years
|
0.330
|
1.391
|
0.729
| | | | |
|
< 2 years
|
ref
| | | | | | |
|
CRPd
|
0.321
|
1.378
|
0.046
|
0.344
|
0.169
|
1.411
|
0.042
|
|
Ferritin
|
−0.001
|
0.999
|
0.582
| | | | |
|
Osteoporosis
|
−0.064
|
0.938
|
0.905
| | | | |
|
Osteoarthritis
|
0.446
|
1.562
|
0.482
| | | | |
|
Hysterectomy
|
−0.087
|
0.917
|
0.688
| | | | |
|
Oophorectomy
|
−0.241
|
0.786
|
0.702
| | | | |
|
Salpingectomy
|
−0.251
|
0.778
|
0.452
| | | | |
|
Fibroids
|
−1.240
|
0.289
|
0.337
| | | | |
|
CADd
|
1.421
|
4.140
|
0.051
|
1.609
|
0.630
|
4.996
|
0.011
|
|
HLD
|
0.366
|
1.442
|
0.363
| | | | |
|
Non-ovarian cancer
|
−1.040
|
0.354
|
0.159
|
−1.351
|
0.733
|
0.259
|
0.065
|
- EtOH Alcohol, CHC Current hormonal contraception, OCP Oral contraceptive pill, CRP C reactive protein, CAD Coronary artery disease, HLD Hyperlipidemia
- a All univariable regressions were adjusted for baseline variables including age, race/ethnicity, BMI, parity and current hormonal replacement therapy (HRT) use
- b Multivariable regressions included the baseline variables (age, race/ethnicity, BMI, parity, HRT) and eligible variables from univariable analyses with cut-off p value < 0.25
- c For the “Breastfeed” variable, the reference for parity is one instead of none
- d These variables demonstrated significant associations with CA125 level ≥ 35 U/ml in the multivariable logistic regression model
