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Table 6 Associations between candidate correlating factors and CA125 level ≥ 35 U/ml among postmenopausal women (N = 1116) by univariable and multivariable logistic regressions

From: Factors associated with serum CA125 level in women without ovarian cancer in the United States: a population-based study

Variables Univariable logistic regressionsa Multivariable logistic regressionsb
Effect estimate OR (odds ratio) P value Effect estimate Standard error OR P value
Smoking
 Current −0.726 0.484 0.393     
 Former 0.250 1.283 0.652     
 None ref       
Caffeine −0.0013 0.999 0.449     
Age of menarche
  > 12 −0.475 0.622 0.334     
  ≤ 12 ref       
Breastfeedcd 0.765 2.148 0.066 0.899 0.402 2.457 0.026
OCP duration
 10+ years −0.123 0.884 0.876     
 5–10 years −0.329 0.720 0.499     
 2–5 years 0.330 1.391 0.729     
  < 2 years ref       
CRPd 0.321 1.378 0.046 0.344 0.169 1.411 0.042
Ferritin −0.001 0.999 0.582     
Osteoporosis −0.064 0.938 0.905     
Osteoarthritis 0.446 1.562 0.482     
Hysterectomy −0.087 0.917 0.688     
Oophorectomy −0.241 0.786 0.702     
Salpingectomy −0.251 0.778 0.452     
Fibroids −1.240 0.289 0.337     
CADd 1.421 4.140 0.051 1.609 0.630 4.996 0.011
HLD 0.366 1.442 0.363     
Non-ovarian cancer −1.040 0.354 0.159 −1.351 0.733 0.259 0.065
  1. EtOH Alcohol, CHC Current hormonal contraception, OCP Oral contraceptive pill, CRP C reactive protein, CAD Coronary artery disease, HLD Hyperlipidemia
  2. a All univariable regressions were adjusted for baseline variables including age, race/ethnicity, BMI, parity and current hormonal replacement therapy (HRT) use
  3. b Multivariable regressions included the baseline variables (age, race/ethnicity, BMI, parity, HRT) and eligible variables from univariable analyses with cut-off p value < 0.25
  4. c For the “Breastfeed” variable, the reference for parity is one instead of none
  5. d These variables demonstrated significant associations with CA125 level ≥ 35 U/ml in the multivariable logistic regression model